Pathogenesis And Consequences Of Zika Virus Infection
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Abstract
Following the 2015 outbreak in Brazil, the Zika virus—a member of the Flaviviridae family that causes a disease spread by mosquitoes—became more well-known globally. There have been concerning indications during this outbreak that Zika infection may have contributed to fetal microcephaly and other neurodevelopmental disorders. The virus also results in thrombocytopenia, multi-organ failure, and uveitis, an inflammatory condition that can cause blindness in adults. It may spread through sexual contact and the placenta, a mode of transmission uncommon in other flaviviruses. The fetus eventually develops microcephaly and neurological abnormalities as a result of the virus infection. Despite its severity, no particular medication or vaccine is currently available to treat it. In conclusion, knowledge of ZIKV pathogenesis may aid in the fight against its worldwide outbreak.
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