Effect Of Selenium In Altering Hypertension Within Indian Population: A Review

Abstract

Nowadays Hypertension is a most common Cardiovascular disorder throughout the world. It causes many underlying disease such as pathological condition of heart, blood vessel damage, myocardial infarction, stroke etc. Our review shows that the effect of a micronutrient Selenium (Se), in altering hypertension in Indian population irrespective of age, sex, life-style etc. Selenium is a natural anti-oxidant, has potential role in development and progression of cardio-vascular disease. Se maintains normal functioning of smooth muscle & heart. Experimental evidence shows Selenium level has significant negative relationship that is when Se level decreases, blood pressure increases as oxidative stress increases. Glutathione peroxidase, a selenoprotein, is a protein containing Se have the capacity to protect vascular smooth muscle. Therefore low Se intake leads to severe changes in blood vessel wall. In athlete’s & body-builders strenuous exercise produce free radicals which also contributes on oxidative stress. So balancing of serum Se level is too much necessary for vascular system as it prevent CVD by lowering oxidative stress and inflammatory response. But the studies varied greatly in terms of study population & Se level measured in subject. Therefore repeated trials & Se levels are needed to fully finalized the relationship between Se and Hypertension.