Anti-Inflammatory and Anti-Oxidant effects of Manilkara zapota and Hylocereus undantus: A Complete Review

Main Article Content

Arpit Vaishnav
Foram Tapan Mehta
Dr. Pragnesh Patani

Abstract

This article summarises recent scientific results regarding the anti-inflammatory and antioxidant activities of the phytochemical elements in Manilkara zapota (i.e,Sapodilla) and Hylocereus undatus (i.e, Dragon fruit). The Central American native sapodilla has strong antioxidant properties thanks to its rich composition of bioactive substances, which includes polyphenols and vitamins. Sapodilla may be a contender for treating inflammatory ailments like arthritis and gastrointestinal issues. According to recent studies, it has anti-inflammatory properties. Another tropical treasure bursting with antioxidants is Hylocereus undatus, also referred to as dragon fruit. Its beautiful pink flesh is packed with betalains, polyphenols, and significant amounts of vitamin C, all of which add to its strong antioxidant capacity. Additionally, by blocking inflammatory cytokines and enzymes, dragon fruit has demonstrated promise in reducing inflammation.

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How to Cite
Arpit Vaishnav, Foram Tapan Mehta, & Dr. Pragnesh Patani. (2024). Anti-Inflammatory and Anti-Oxidant effects of Manilkara zapota and Hylocereus undantus: A Complete Review. Journal of Advanced Zoology, 45(1), 291–299. https://doi.org/10.53555/jaz.v45i1.3761
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Articles
Author Biographies

Arpit Vaishnav

Student, Khyati College of Pharmacy, Palodia, Ahmedaba

Foram Tapan Mehta

Assistant Professor, Khyati College of Pharmacy, Palodia, Ahmedabad

Dr. Pragnesh Patani

Principal, Khyati College of Pharmacy, Palodia, Ahmedabad

References

Nunes CDR, Barreto Arantes M, Menezes de Faria Pereira S, Leandro da Cruz L, de Souza Passos M, Pereira de Moraes L, Vieira IJC, Barros de Oliveira D. Plants as Sources of Anti-Inflammatory Agents. Molecules. 2020 ;25(16):3726.

S.Kumar, Satti Naresh, Singh Kuldeep. “Anti-Inflammatory Activity of Herbal Plants: A Review.; IJAPBC. 2013; 2(2); 2277 – 4688.

Parle Milind. Chickoo: a wonderful gift from nature. Int. J. Res. Ayurveda Pharm; August 2015; 6(4); 544-550.

Mansi Chaudhary, Ridhima Singh1, Ekta Singh Chauhan. A short review on sapota (manilkara zapota) Fruit: nutrition profile, Ethnomedicinal values, and Utilization in the food industry. IJCRT; July 2023; 11(7).

Pandya Prutha Hitendraprasad, Karunakar Hegde, A R Shabaraya. Hylocereus undatus (Dragon Fruit): A Brief Review. Int. J. Pharm. Sci. Rev. Res., Jan 2020; 60(1), 55-57.

Huang, Y.; Brennan, M.A.; Kasapis, S.; Richardson, S.J.; Brennan, C.S. Maturation Process, Nutritional Profile, Bioactivities and Utilisation in Food Products of Red Pitaya Fruits: A Review. Foods 2021, 10, 2862.

Purilla Salomi et al. A Review on Plant profile and Pharmacological activities of Hylocereus undatus fruit. Int. J. Res. Ayurveda Pharm. 2021;12(3):103-105

Slade D, Ferreira D, Marais JPJ. Circular dichroism, a powerful tool for the assessment of absolute configuration of flavonoids; Phytochemistry, 2005; 66:2177-2215.

G. Venkateswara Rao. Phytoconstituents from the leaves and seeds of Manilkara zapota Linn. Der Pharmacia Lettre, 2014, 6 (2):69-73.

Moustafa H Baky, Amal M Kamal, Mohamed R Elgindi, Eman G Haggag. A Review on Phenolic Compounds from Family Sapotaceae. JPP 2016; 5(2): 280-287.

Joshi M, Prabhakar B. Phytoconstituents and pharmaco-therapeutic benefits of pitaya: A wonder fruit. J Food Biochem. 2020 Jul;44(7): 13260.

Yang, S. Chemical composition and in vitro evaluation of the cytotoxic and antioxidant activities of supercritical carbon dioxide extracts of pitaya (dragon fruit) peel. Chemistry Central Journal. April 2014; 8(1), 1–7.

Ahmed, A.U. An overview of inflammation: mechanism and consequences. Front. Biol. Jan.2011, 6(4): 274–281.

Medzhitov, R. Origin and physiological roles of inflammation. Nature 2008, 454(7203): 428–435.

Pervical M. Understanding the natural management of pain and inflammation, Clinical Nutrition insights. 1999:4:1-5.

Ferrero-Miliani L, Nielsen O, Andersen P, Girardin S. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1β generation. Clin Exp Immunol. 2007; 147:227–235.

Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017 Dec 14; 9(6):7204-7218.

Arai K, Lee F, Miyajima A, Miyatake S, Arai N, Yokota T. Cytokines: coordinators of immune and inflammatory responses. Annu Rev Biochem 1991; 59: 783-836.

Hossain, Hemayet. Evaluation of Anti-inflammatory Activity and Total Flavonoids Content of Manilkara zapota (Linn.) Bark. International Journal of Pharmacy. Int. J. Pharm. Phytopharmacol. Res. Aug; 2012; 2(1): 35-39.

Ganguly A, Al Mahmud Z, Kumar Saha S, Abdur Rahman SM. Evaluation of antinociceptive and antidiarrhoeal properties of Manilkara zapota leaves in Swiss albino mice. Pharm Biol. (2016) 54:1413–9.

Konuku K, Karri KC, Gopalakrishnan VK, Hagos Z, Kebede H, Naidu TK, et al. Anti-inflammatory activity of Manilkara zapota leaf extract. Int J Curr Pharm Res. (2017) 9:130–34.

Saleh HA, Yousef MH, Abdelnaser A. The anti-inflammatory properties o phytochemicals and their effects on epigenetic mechanisms involved in TLR4/NF-κB- mediated inflammation. Front Immunol. (2021) 12:1–29. 65.

Jahan F, Sariful Islam Howlader M, Kanti Dey S, Hira A, Ahmed A, et al. Evaluation of Anti-inflammatory Activity and Total Flavonoids Content of Manilkara zapota (Linn.) Bark. Int J Pharma Phytopharmacol Res. (2012) 35:35–9.

Liu YP, Yan G, Guo JM, Liu YY, Li YJ, Zhao YY, et al. Prenylated Coumarins from the Fruits of Manilkara zapota with Potential Anti-inflammatory Effects and Anti-HIV Activities. J Agric Food Chem. (2019) 67, 11942–11947.

Kamala kararao K, Krishna Chaithanya K, Gopalakrishnan VK, Hagos Z, Arefaye KM, Noyola PP, et al. Apigenin-7-O-B-D-glucuronide methyl ester isolated from Manilkara zapota leaves. Int. J. Pharm. Qual Assur. (2017) 8:130–134.

Yong KY, Shukkoor MSA, Chin JH. Analgesic activity of chloroform and methanolic leaf extracts of Manilkara zapota. Mater Today Proc. (2019) 29:20–5.

Kim JM, Heo HJ. The roles of catechins in regulation of systemic inflammation. Food Sci Biotechnol Korean Soc Food Sci Technol. (2022) 31:957–70.

Rivas-Gastelum MF, Garcia-Amezquita LE, Garcia-Varela R and Sánchez-López. Manilkara zapota “chicozapote” as a fruit source of health-beneficial bioactive compounds and its effects on chronic degenerative and infectious diseases, a review. Front. Nutr. July 2023; 10:1194283.

Nishikito DF, Borges ACA, Laurindo LF, Otoboni AMMB, Direito R, Goulart RA, Nicolau CCT, Fiorini AMR, Sinatora RV, Barbalho SM. Anti-Inflammatory, Antioxidant, and Other Health Effects of Dragon Fruit and Potential Delivery Systems for Its Bioactive Compounds. Pharmaceutics. 2023 Jan 3;15(1):159.

Putri, M.D, Wiboworini, B, Dirgahayu, P. Red dragon fruit juice in reducing ros levels and insulin resistance in rats with type 2 diabetes mellitus model. J. Nutr. 2021; 10; 6–14.

Saenjum, C.; Pattananandecha, T.; Nakagawa, K. Antioxidative and anti-inflammatory phytochemicals and related stable paramagnetic species in different parts of dragon fruit. Molecules 2021, 26, 3565.

Eldeen, I.M.S.; Foong, S.Y.; Ismail, N.; Wong, K.C. Regulation of pro-inflammatory enzymes by the dragon fruits from Hylocereus undatus (Haworth) and squalene-its major volatile constituents. Pharmacogn. Mag. 2020, 16, 81.

Nishikito DF, Borges ACA, Laurindo LF, Otoboni AMMB, Direito R, Goulart RA, Nicolau CCT, Fiorini AMR, Sinatora RV, Barbalho SM. Anti-Inflammatory, Antioxidant, and Other Health Effects of Dragon Fruit and Potential Delivery Systems for Its Bioactive Compounds. Pharmaceutics. 2023 Jan 3;15(1):159.

Al-Radadi, N.S. Biogenic proficient synthesis of (Au-NPs) via aqueous extract of Red Dragon Pulp and seed oil: Characterization, antioxidant, cytotoxic properties, anti-diabetic anti-inflammatory, anti-Alzheimer and their anti-proliferative potential against cancer cell lines. Saudi J. Biol. Sci. 2022, 29, 2836–2855.

Sunitha Dontha. “A review on antioxidant methods”. Asian Journal of Pharmaceutical and Clinical Research. Oct. 2016; 9(8); 14-32.

Duracková Z. Some current insights into oxidative stress. Physiol Res 2010;59(4):459-69.

Halliwell B. Uric acid: An example of antioxidant evaluation. In: Cadenas E, Packer L, editors. Handbook of Antioxidants. New York: Marcel Dekker; 1996. p. 243-56.

Achakittirungrod S, Okonogi S, Poonpohn SC. Study on antioxidant activity of certain plants in Thailand: Mechanism of antioxidant action of guava leaf extract. Food Chem 2007;103(2):381-8.

Pisoschi, A.M.; Pop, A. The role of antioxidants in the chemistry of oxidative stress: A review. Eur. J. Med. Chem. 2015, 97, 55–74.

Bano, Mehnaz & Ahmed, Bilal. (2017). Manilkara zapota (L.) P.Royen (Sapodilla): A Review.; IJARIIT 3(6); 1364-1371.

S. Chanda and R. Dave “In vitro models for antioxidant activity evaluation and some medicinal plants possessing antioxidant properties: An overview” Afr. J. Microbiol. Res., 3: 981-996, 2009.

S. V. Chanda and K. V. Nagani “Antioxidant Capacity of Manilkara zapota L. Leaves Extracts Evaluated by Four in vitro Methods”, Nature and Science, 8(10): 260-266, 2010.

Kulkarni, Anand & Policegoudra, Rudragoud & Aradhya, s.m. Chemical composition and antioxidant activity of sapota (Achras sapota Linn.) fruit. Journal of Food Biochemistry. June 2003; 31(3). 399 - 414.

Adrian Tulloch, Andrea Goldson-Barnaby, Dennis Bailey & Sonal Gupte. Manilkara zapota (Naseberry): Medicinal Properties and Food Applications, International Journal of Fruit Science.2020; 20; s1-s7.

Kannan Gomathy. Comparison of antioxidant potential in pulp and peel extracts of Manilkara zapota (L.) P. Royen. Academic Journals. July 2013; 12(31); 4936-4943.

Pientaweeratch S, Panapisal V, Tansirikongkol A. Antioxidant, anti-collagenase and anti-elastase activities of Phyllanthus emblica, Manilkara zapota and silymarin: an in vitro comparative study for anti-aging applications. Pharm Biol. (2016) 54:1865–72.

Hernández, Y.D.O.; Salazar, J.A.C. Pitahaya (Hylocereus spp.): A short review. Comun. Sci. 2012, 3, 220–237.

Jeronimo, M.C.; Orsine, J.V.C.; Novaes, M.R.C.G. Nutritional pharmacological and toxicological characteristics of pitaya (Hylocereus undatus): A review of the literature. Afr. J. Pharm. Pharmacol. 2017, 11, 300–304.

Safira, A.; Savitri, S.L.; Putri, A.R.B.; Hamonangan, J.M.; Safinda, B.; Solikhah, T.I.; Khairullah, A.R.; Puspitarani, G.A. Review on the pharmacological and health aspects of Hylocereus or Pitaya: An update. J. Drug Deliv. Ther. 2021, 11, 297–303.

Harahap, N.S.; Amelia, R. Red dragon fruit (Hylocereus polyrhizus) extract decreases lactic acid level and creatine kinase activity in rats receiving heavy physical exercise. Open Access Maced. J. Med. Sci. 2019, 7, 2232. [CrossRef] [PubMed]

Rusip, G.; Ilyas, S.; Lister, I.N.E.; Ginting, C.N.; Mukti, I. The effect of ingestion of red dragon fruit extract on levels of malondialdehyde and superoxide dismutase after strenuous exercise in rats (Rattus norvegicus). F1000Research 2021, 10, 1061.

Putri, M.D.; Wiboworini, B.; Dirgahayu, P. Red dragon fruit juice in reducing ros levels and insulin resistance In rats with type 2 diabetes mellitus model. J. Nutr. 2021, 10, 6–14.

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