Multifactorial Aspects Influencing Non-Alcoholic Fatty Liver Disease (Nafld)
DOI:
https://doi.org/10.17762/jaz.v44iS-1.1248Keywords:
Non-Alcoholic Fatty Liver Disease; metabolic associated fatty liver disease; Nonalcoholic steatohepatitis; diabetics; Genetic factors; Thyroid dysfunctionAbstract
Nonalcoholic fatty liver disease (NAFLD) is a growing public health concern, with a prevalence of up to 25% worldwide. While once considered a benign condition, NAFLD is now recognized as a major cause of chronic liver disease, liver failure, and hepatocellular carcinoma. The pathogenesis of NAFLD is multifactorial and involves a complex interplay between genetic, environmental, and metabolic factors. In this review, we provide an overview of the multifactorial aspects of NAFLD, including genetic predisposition, insulin resistance, dyslipidemia, gut microbiota, dietary factors, and physical inactivity. We also discuss the role of inflammation, oxidative stress, and hepatic steatosis in the progression of NAFLD to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Finally, we review the current and emerging therapies for NAFLD and NASH, including lifestyle modifications, pharmacological interventions, and surgical approaches. The multifactorial nature of NAFLD requires a comprehensive approach to diagnosis, treatment, and prevention, with a focus on addressing the underlying metabolic and environmental factors that contribute to its development and progression.
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Copyright (c) 2023 Ms. Rachana Raveendran, Dr. Josephine A, Dr. Kalaiselvi P, Dr. V Sureka , Ms. Kanchana S B, Ms. Thahira Abdulla, Ms. Swathi T, Ms. Pinchulatha K, Ms. Ambili PV, Dr. Dinesh Roy D
This work is licensed under a Creative Commons Attribution 4.0 International License.