Multifactorial Aspects Influencing Non-Alcoholic Fatty Liver Disease (Nafld)

Authors

  • Ms. Rachana Raveendran Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu https://orcid.org/0009-0007-3225-3650
  • Dr. Josephine A Meenakshi Academy of Higher Education and Research https://orcid.org/0000-0002-5474-0034
  • Dr. Kalaiselvi P Department of Medical Biochemistry, Dr. ALM PGIBMS, University of Madras, Taramani campus, Chennai, India
  • Dr. V Sureka Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India
  • Ms. Kanchana S B Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu
  • Ms. Thahira Abdulla Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu
  • Ms. Swathi T Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu
  • Ms. Pinchulatha K Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu
  • Ms. Ambili PV Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India
  • Dr. Dinesh Roy D a:1:{s:5:"en_US";s:102:"CEO & Senior Cytogeneticist https://orcid.org/0009-0005-7124-148X

DOI:

https://doi.org/10.17762/jaz.v44iS-1.1248

Keywords:

Non-Alcoholic Fatty Liver Disease; metabolic associated fatty liver disease; Nonalcoholic steatohepatitis; diabetics; Genetic factors; Thyroid dysfunction

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a growing public health concern, with a prevalence of up to 25% worldwide. While once considered a benign condition, NAFLD is now recognized as a major cause of chronic liver disease, liver failure, and hepatocellular carcinoma. The pathogenesis of NAFLD is multifactorial and involves a complex interplay between genetic, environmental, and metabolic factors. In this review, we provide an overview of the multifactorial aspects of NAFLD, including genetic predisposition, insulin resistance, dyslipidemia, gut microbiota, dietary factors, and physical inactivity. We also discuss the role of inflammation, oxidative stress, and hepatic steatosis in the progression of NAFLD to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Finally, we review the current and emerging therapies for NAFLD and NASH, including lifestyle modifications, pharmacological interventions, and surgical approaches. The multifactorial nature of NAFLD requires a comprehensive approach to diagnosis, treatment, and prevention, with a focus on addressing the underlying metabolic and environmental factors that contribute to its development and progression.

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Author Biographies

Ms. Rachana Raveendran, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu

Rachana Raveendran is a dedicated Ph.D. scholar at Meenakshi Academy of Higher Education and Research in Chennai, Tamil Nadu, specializing in Biochemistry within the field of medicine. Her research focuses on "Biochemical and Genetic Aspects in the Pathogenesis of Cardiovascular Events and Non-alcoholic Fatty Liver in Young Adults," with a particular emphasis on the Adiponectin encoding (ADIPOQ) gene polymorphism. Through her academic journey and research endeavors, Rachana is committed to advancing our understanding of the intricate relationship between genetics and biochemical factors in the development of cardiovascular issues and non-alcoholic fatty liver disease in young adults. Her work contributes to the broader knowledge of these health concerns and holds promise for future medical advancements.

Dr. Josephine A, Meenakshi Academy of Higher Education and Research

Dr. A Josephine is a distinguished scientist affiliated with the Central Research Laboratory at Meenakshi Academy of Higher Education and Research in Chennai, Tamil Nadu. Her professional journey has been marked by significant contributions to the field of research and academia. With a focus on areas such as biochemistry, her work encompasses a wide range of scientific investigations and advancements. Dr. Josephine's expertise and dedication to research have made a notable impact on the scientific community, both locally and internationally. Her work, which may include research publications, projects, and collaborations, continues to further the boundaries of knowledge and innovation in her field.

Dr. Kalaiselvi P, Department of Medical Biochemistry, Dr. ALM PGIBMS, University of Madras, Taramani campus, Chennai, India

Dr. P Kalaiselvi is a distinguished Professor within the Department of Medical Biochemistry at Dr. ALM PGIBMS, University of Madras, situated at the Taramani campus in Chennai, India. Her academic and professional journey is marked by significant contributions to the field of medical biochemistry. Dr. P Kalaiselvi' s expertise and dedication have left an indelible mark on the academic and research community. Her work underscores a profound commitment to advancing knowledge in the field of medical biochemistry, making her a notable figure in higher education and scientific inquiry.

Dr. V Sureka , Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India

Dr. V Sureka holds the esteemed position of Dean of Research at Meenakshi Academy of Higher Education and Research (MAHER) in Chennai, Tamil Nadu. Her significant role, both in academia and administration, is characterized by a steadfast dedication to advancing research and upholding academic excellence within the institution. Dr. SUREKA's contributions are instrumental in cultivating an environment rich in research opportunities and nurturing the expansion of knowledge at MAHER. In her capacity as Dean of Research, she is pivotal in shaping the institution's research priorities and actively champions scholarly pursuits. Her unwavering commitment to the academic and research community is clearly reflected in her efforts to propel research initiatives at MAHER, ultimately benefiting students, faculty, and the wider academic audience.

Ms. Kanchana S B, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu

Kanchana SB is a dedicated Research Scholar specializing in the Sciences, with a particular focus on Biochemistry. She is affiliated with the Faculty of Sciences at Meenakshi Academy of Higher Education and Research (MAHER). Kanchana's academic journey is characterized by her unwavering commitment to the field of biochemistry, where her research efforts are dedicated to unraveling the complexities of biochemical processes. Her work significantly enhances our understanding of these intricate processes and their practical applications, establishing her as a valuable presence in the academic and research community. Kanchana's strong dedication to advancing scientific knowledge and her keen focus on rigorous inquiry underscore her potential as a valuable contributor to the field of biochemistry and the broader scientific community.

Ms. Thahira Abdulla, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu

Thahira Abdulla is a dedicated Research Scholar in the field of genetics within the Faculty of Allied Health Science at Meenakshi Academy of Higher Education and Research (MAHER) in Chennai, Tamil Nadu. Her academic journey is characterized by a strong commitment to advancing knowledge in the field of genetics. Thahira's research specialization focuses on uncovering the intricacies of genetic processes, contributing significantly to our understanding of these fundamental biological mechanisms. Her presence in the academic and research community reflects her potential as a valuable contributor to the field of genetics and the broader realm of Allied Health Science, with the promise of making notable contributions to scientific inquiry and the advancement of knowledge.

Ms. Swathi T, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu

Swathi T is a dedicated Research Scholar specializing in genetics within the Faculty of Allied Health Science at Meenakshi Academy of Higher Education and Research (MAHER) in Chennai, Tamil Nadu. Her academic journey is marked by a steadfast commitment to advancing knowledge in the field of genetics. Swathi's research focus lies in unraveling the complexities of genetic processes, making substantial contributions to our understanding of fundamental biological mechanisms. Her presence in the academic and research community underscores her potential as a valuable contributor to the field of genetics and the broader domain of Allied Health Science, with the promise of making noteworthy contributions to scientific inquiry and knowledge advancement.

Ms. Pinchulatha K, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu

Pinchulatha K is a dedicated scholar in the field of Anatomy within the Faculty of Medicine at Meenakshi Academy of Higher Education and Research (MAHER) located in Chennai, Tamil Nadu. Her academic journey is marked by a resolute commitment to advancing knowledge within the realm of medical anatomy. Pinchulatha's research efforts are focused on unraveling the intricate details of anatomical structures and their applications, making significant contributions to our understanding of the human body. Her presence in the academic and medical research community reflects her potential as a valuable contributor to the field of Anatomy and the broader domain of Medicine, with the promise of making notable contributions to scientific inquiry and the advancement of knowledge.

Ms. Ambili PV, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India

Ambili PV is a dedicated scholar in the field of Public Health within the Faculty of Allied Health Science at Meenakshi Academy of Higher Education and Research (MAHER) in Chennai, Tamil Nadu. Her academic journey is characterized by a steadfast commitment to advancing knowledge in the realm of public health. Ambili's research endeavors are focused on addressing critical issues related to public health, contributing significantly to our understanding of healthcare and its impact on communities. Her presence in the academic and healthcare research community underscores her potential as a valuable contributor to the field of Public Health and the broader domain of Allied Health Science, with the promise of making noteworthy contributions to scientific inquiry and knowledge advancement.

Dr. Dinesh Roy D, a:1:{s:5:"en_US";s:102:"CEO & Senior Cytogeneticist

Dr. Dinesh Roy D, CEO of Genetika in Thiruvananthapuram, boasts a robust academic and professional background in genetics with M.Phil and Doctorate degrees, as evidenced by over 160 publications in prestigious national and international journals. He actively engages in over 30 national and international conferences, fostering global collaboration. Dr. Roy's mentorship extends to guiding more than 200 M.Sc dissertation projects, 15 M.Phil candidates, and over 20 PhD theses, significantly contributing to the research community. His extensive expertise in karyotyping, PCR, Prenatal diagnosis, ELISA, and biochemical tests plays a vital role in genetic research and diagnostics, advancing the field with transformative biomarkers and multifaceted skills.

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Published

2023-11-01

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