Endocrine Autoimmunity in Association with Female Infertility

Abstract

Infertility is the inability to conceive after a year of regular unprotected sexual intercourse, affecting 10-15% of couples. Advanced age, obesity, and certain medications can hinder fertility. Endocrine autoimmunity is increasingly recognized as a significant contributor to female infertility, often complicating various gynecological conditions. Autoimmune issues involving the hypothalamus, pituitary gland, thyroid, adrenal glands, and ovaries can impact fertility. A multidisciplinary approach is essential for diagnosing infertility, with a crucial focus on identifying potential endocrine disorders. Here we discuss how to identify endocrine autoimmune patients with ovulatory dysfunction. Women must be advised about limiting factors to be avoided, to protect their fertility. A comprehensive understanding of the underlying mechanisms, coupled with appropriate diagnostic and therapeutic approaches, is crucial for effectively managing this complex condition and helping women achieve their reproductive goals.