Association Between Nonalcoholic Fatty Liver Disease And Inflammatory Periodontal Disease
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Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) and inflammatory periodontal disease (IPD) are both prevalent chronic conditions with growing recognition of potential interplay. Understanding their association is crucial for comprehensive disease management.
Materials and Methods: A cross-sectional study was conducted among 300 participants, including 150 with NAFLD and 150 controls without NAFLD. Diagnosis of NAFLD was confirmed by liver ultrasound, while IPD was assessed through clinical periodontal examination. Demographic data, medical history, and lifestyle factors were recorded. Statistical analyses, including chi-square tests and logistic regression, were performed to determine the association between NAFLD and IPD.
Results: Among participants with NAFLD, 65% were found to have IPD compared to 35% in the control group. Logistic regression analysis revealed a significant association between NAFLD and IPD (OR = 2.5, 95% CI: 1.7–3.8, p < 0.001). Additionally, individuals with NAFLD had higher mean periodontal pocket depth (4.2mm vs. 3.1mm) and greater gingival inflammation compared to controls.
Conclusion: This study demonstrates a significant association between NAFLD and IPD, suggesting a potential bidirectional relationship. Comprehensive healthcare strategies addressing both conditions may be warranted to mitigate associated health risks. Further longitudinal studies are needed to elucidate the underlying mechanisms and explore therapeutic interventions targeting this comorbidity.
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