Evaluation Of Preliminary, Chromatographic And Antioxidant Activity Of Commiphora Mukul
Main Article Content
Abstract
The qualitative analysis, chromatography, and antioxidant studies of theCommiphoramukul extract are the topics of this research.
Physiochemical parameters such as Ph (3.6), total ash value (2.16%), acid insoluble matter (0.25%), water soluble value (41.29%), and moisture content (7.2%) were measured for this study.The important information gathered throughout the study indicates that saponins are absent from a certain plant, it has a variety of phytochemicals including alkaloids, tannin, carbohydrates, protein, and steroids.These plant-based bioactive substances have a distinct, typical biological effect on human anatomy. Rf=0.89 for Googlesterone was obtained with a good resolution in TLC tests when the mobile phase (toluene: ethyl acetate) was in the ratio (93:07)v/v under UV light at 272 nm. According to the investigations, Commiphoramukul is a rich source of a variety of secondary metabolites. This can be further explored by economically isolating and identifying biologically active molecules with medical use. The alcoholic percentage was
spectroscopically analyzed using UV spectra, which reveal the highest observance of the alcoholic fraction of Plant.The current study's findings demonstrate that alcoholic plant extract has strong in vitro antioxidant activity at increasing concentrations in both DPPH free radical scavenging activity and FeCl3 reduction power.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Reddy L, Odhav B, Bhoola KD., 2003. Natural product for cancer prevention: a global perspective.
Pharmacology Therapeutics 99: 1-13.
Padma TV., 2005. Ayurveda. Nature 436(7050): 486.
Tag H, Das AK, Loyi H. ,2007. Anti-inflammatory plants used by the Khamti tribe of Lohit district in
eastern Arunachal Pradesh, India. Natural Product Radiance 6(4): 334-340.
Sangle V. D., Nadkarni S. D., Vahalia M. K., Darp M. S.,2004 The study of effect of ayurvedic processing
of Commiphorawightii on gastric irritancy index in experimental animals. Indian Drugs.41(5):268–271.
Khan RA, Aslam M, Ahmed S., 2016. Evaluation of toxicological profile of a polyherbal formulation.
Pharmacology and Pharmacy 7(1): 56-69.
Kayser O, Kidderlen AF, Croft SL., 2000. Natural products as potential anti-parasitic drugs. Acta Trop. 77:
-314.
Raskin I, Ribnicky DM, Komarnytsky S, Ilic N, Poulev A, Borinker N, Moreno DA, Ripoll C, Yakoby N.,
Plants and human health in the twenty-first century. Trends Biotechnology 20: 522-531.
Bhati A.,1950 Essential oil from the resin of Commiphoramukul, Hook. Ex. stocks. Journal of the Indian
Chemical Society.27:436–440.
Pratheeshkumar P, Sreekala C, Zhang Z, Budhraja A, Ding S, Son YO, Wang X, Hitron A, Hyun-Jung K,
Wang L, Lee JC, Shi X., 2012. Cancer prevention with promising natural products: mechanisms of action
and molecular targets. Anticancer Agents Med Chem. 12(10): 1159-1184.
Patil V. D., Nayak U. R., Dev S.,1972 Chemistry of Ayurvedic crude drugs—I: Guggulu (resin from
Commiphoramukul)—1: steroidal constituents. Tetrahedron.28(8):2341–2352. doi: 10.1016/s0040-
(01)93577.
Whistler W, Arthur.,2000. Tropical Ornamentals: A Guide. Timber Press Inc. Oregon 0-88192-448-2.
Kirtikar KR, Basu BB. 2006. Indian Medicinal Palnt(2nd Edition, Vol. 4). Allahabad: Allahabad Lalit
Mohan Basu Padma T V (2005) India Ayurveda Nature. pp 436-486.
Saxena V. K., Sharma R. N.,1998 Constituents of the essential oil from Commiphoramukul gum resin.
Journal of Medicinal and Aromatic Plant Sciences.20:55–56.
Rücker G.,1972 Monocyclic diterpenes from Indian gugul resin (Commiphoramukul) Archiv der
Pharmazie.305(7):486–493. doi: 10.1002/ardp.19723050703.
The Ayurvedic Pharmacopoeia of India (Formulations)2007 1st. New Delhi, India: Department of Indian
Systems of Medicine and Homeopathy, Ministry of Health and Family Welfare, Government of India.
The Ayurvedic Pharmacopoeia of India2001. 1st. New Delhi, India: Department of Indian Systems of
Medicine and Homeopathy, Ministry of Health and Family Welfare, Government of India.
Urizar N. L., Moore D. D.,2003Gugulipid: a natural cholesterol-lowering agent. Annual Review of
Nutrition.23:303–313.
Indian Pharmacopoeia.(1996) New Delhi, India: The Controller of Publications.
Masten S. A.,2005Gum Guggul and Some of Its Steroidal Constituents: Review of Toxicological Literature.
Vol. 2. Durham, NC, USA: US Department of Health and Human Services, National Toxicology Program
(NTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health.
Karan M., Kumar V., Suneja V., Vasisht K.,2009 Commercial herbal anti-inflammatory formulations—a
survey. Pharmacos.36:14–25.
Prasad R. S., Dev S.,1976 Chemistry of ayurvedic crude drugs—IV: guggulu (resin from
commiphoramukul—4 absolute stereochemistry of mukulol. Tetrahedron.32(12):1437–1441.
Patil V. D., Nayak U. R., Dev S.,1973 Chemistry of ayurvedic crude drugs—II. Guggulu (resin from
Commiphoramukul)-2: diterpenoid constituents. Tetrahedron.29(2):341–348.
Francis J. A., Raja S. N., Nair M. G.,2014 Bioactive terpenoids and guggulusteroids from
Commiphoramukul gum resin of potential anti-inflammatory interest. Chemistry and
Biodiversity.1(11):1842–1853.
Matsuda H., Morikawa T., Ando S., et al.,2020 Absolute stereostructures of polypodane-type triterpenes,
myrrhanol A and myrrhanone A, from guggul-gum resin (the resin of Balsamodendronmukul) Chemical
and Pharmaceutical Bulletin.52(10):1200–1203.
Kimura I., Yoshikawa M., Kobayashi S., et al.,2001 New triterpenes, myrrhanol A and myrrhanone A, from
guggul-gum resins, and their potent anti-inflammatory effect on adjuvant-induced air-pouch granuloma of
mice. Bioorganic and Medicinal Chemistry Letters. 11(8):985–989.
Xu J., Guo Y., Zhao P., et al.,2011 Neuroprotective cadinane sesquiterpenes from the resinous exudates of
Commiphoramyrrha .Fitoterapia.82(8):1198–1201.
27.M. Oyaizu ,1986, Studies on product of browning reaction prepared from glucose
amine,JapaneseJournal of Nutrition,44,307.
28.Braca, A., Tommasi, N.D., Bari, L.D., et al.,2001Antioxidant Principles from Bauhinia Terapotensis.
Journal of Natural Products, 64, 892-895.