An Experimental Study On Phytochemical Screening And Determination Of Anti-Inflammatory Activity Of Terminalia Bellirica Leaves On Animal Model

Abstract

With globalization, consumer market patterns changed. However, dietary and lifestyle modifications are among their long-term effects. Millions of lives have been saved by medications developed and discovered thanks to research in the chemical and pharmaceutical sciences, but prolonged use of these medications has raised concerns about their safety and toxicological effects. Researchers looked at the plants that were previously utilized in Ayurvedic and Chinese medicine to confirm their traditional uses. Consequently, throughout the past few decades, communities' dependence on complementary and alternative therapies has begun to revive. One such plant, Terminalia bellerica, was known as the "king of medicinal plants" in Ayurveda because of its extensive use in herbal concoctions to treat a variety of health issues. The anti-inflammatory properties of Terminalia bellerica are investigated in this work. Following the collection and testing of the plant material for a number of criteria, an in vivo anti-inflammatory investigation was conducted. After Terminalia bellirica was extracted, the results indicate that while flavonoids, phenols, carbohydrates, and saponins were present, tannin and glycosides were not. Paw edema was significantly inhibited by the Terminalia bellirica hydroalcoholic extract at doses of 200 and 300 mg/kg. After a 4-hour injection of carrageenan, the maximum percentage of edema inhibition for the Terminalia bellirica hydroalcoholic extract was recorded at 59.19% and 62.48% for oral doses of 200 and 300 mg/kg of the extract. According to the findings, Terminalia bellirica have notable anti-inflammatory properties.