Therapeutic Efficacy of Lotus (Nelumbo nucifera) Leaves Extract to Manage Diabetes mellitus
Main Article Content
Abstract
Natural bioactive compounds that target pancreatic cells for the prevention and treatment of diabetes mellitus are gaining popularity. The purpose of this research was to investigate the physiologic effects of Lotus leaves on insulin and sugar levels in order to improve diabetes control. The Soxhelt apparatus was used to extract the Lotus ethanol extract, which was diluted with distilled water at two concentrations: 5 mg/ml (5 percent) and 10 mg/ml (10 percent).. Thirty female white albino rats were randomly separated into three groups: G1(n=10) was given distilled water 1ml, G2(n=10) and G3(n=10) were given a single dosage of 5% and 10% extract solution, respectively, daily for ten days. The results showed significant decrease of glucose level in serum after 10 days of treatment G2= 87.36±1.5 and G3=69.7±1.7 and significant increase of insulin level in serum G2= 78.92±1.03 and G3= 89.36±1.46.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Wild, S.; Roglic, G.; Green, A.; Sicree, R.; King, H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27, 1047–1053. DOI: https://doi.org/10.2337/diacare.27.5.1047
Nair, M. Diabetes mellitus, part 1: Physiology and complications. Br. J. Nurs. 2007, 16, 184–188. DOI: https://doi.org/10.12968/bjon.2007.16.3.22974
Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M : Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med,1998, 339:229-234. DOI: https://doi.org/10.1056/NEJM199807233390404
World Health Organization : The WHO Committee on Diabetes Mellitus: Second Report. Technical Report Series 646. World Health Organization, Geneva,1980, p 61.
Kusano S, Abe H : Antidiabetic Activity of White Skinned Sweet Potato (Ipomoea batatas L.) In Obese Zucker Fatty Rats. Biol Pharm Bull,2000, 23:23-26. DOI: https://doi.org/10.1248/bpb.23.23
Huang CF, Chen YW, Yang CY, et al. Extract of lotus leaf (Nelumbo Nucifera) and its active constituent catechin with insulin secretagogue activity. J Agric Food Chem 2011; 59(4): 1087-1094. DOI: https://doi.org/10.1021/jf103382h
ZADEH, Firoozeh Abolhasani, et al. Cytotoxicity evaluation of environmentally friendly synthesis Copper/Zinc bimetallic nanoparticles on MCF-7 cancer cells. Rendiconti Lincei. Scienze Fisiche e Naturali, 2022, 1-7. DOI: https://doi.org/10.1007/s12210-022-01064-x
ROHMAH, Martina Kurnia, et al. Modulatory role of dietary curcumin and resveratrol on growth performance, serum immunity responses, mucus enzymes activity, antioxidant capacity and serum and mucus biochemicals in the common carp, Cyprinus carpio exposed to abamectin. Fish & Shellfish Immunology, 2022, 129: 221-230. DOI: https://doi.org/10.1016/j.fsi.2022.08.042
ARIF, Anam, et al. The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer. International Immunopharmacology, 2023, 114: 109581. DOI: https://doi.org/10.1016/j.intimp.2022.109581
MARGIANA, Ria, et al. Functions and therapeutic interventions of non-coding RNAs associated with TLR signaling pathway in atherosclerosis. Cellular Signalling, 2022, 100: 110471. DOI: https://doi.org/10.1016/j.cellsig.2022.110471
LEI, Zimeng, et al. Detection of abemaciclib, an anti-breast cancer agent, using a new electrochemical DNA biosensor. Frontiers in Chemistry, 2022, 10. DOI: https://doi.org/10.3389/fchem.2022.980162
BASHAR, Bashar S., et al. Application of novel Fe3O4/Zn-metal organic framework magnetic nanostructures as an antimicrobial agent and magnetic nanocatalyst in the synthesis of heterocyclic compounds. Frontiers in Chemistry, 2022, 10. DOI: https://doi.org/10.3389/fchem.2022.1014731