Gestational Diabetes Mellitus And Autonomic Dysfunction: Impact On Preeclampsia Risk
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Abstract
Gestational diabetes mellitus (GDM) and autonomic dysfunction are two closely connected disorders that have received considerable focus in relation to mother health during pregnancy.This review study seeks to provide a thorough analysis of existing research, investigating the complex connection between GDM (gestational diabetes mellitus), autonomic dysfunction, and their combined influence on the likelihood of developing preeclampsia. Gestational diabetes mellitus (GDM) is a prevalent metabolic condition associated with pregnancy, which is characterised by an impaired ability to process glucose and often occurs for the first-time during pregnancy. Preeclampsia is a complex condition characterised by high blood pressure that occurs only during pregnancy and is often linked to negative consequences for both the mother and the foetus. Autonomic dysfunction, characterised by changes in the sympathetic and parasympathetic nerve systems, is now recognised as a possible factor in the development of both gestational diabetes mellitus (GDM) and preeclampsia. This review will examine the complex relationship between gestational diabetes mellitus (GDM), autonomic dysfunction, and preeclampsia, focusing on the epidemiological, clinical, and molecular aspects. This study aims to investigate the reciprocal association between GDM and autonomic dysfunction, examining the potential for one disease to worsen the other. Moreover, the study will examine the several routes via which autonomic dysfunction may impact the occurrence of preeclampsia in the context of GDM, elucidating the underlying pathophysiological processes. This study seeks to enhance our awareness of the intricate relationship between gestational diabetes mellitus (GDM), autonomic dysfunction, and preeclampsia by consolidating the current information. These insights have the potential to facilitate the creation of focused therapies, individualised management approaches, and enhanced risk assessment tools. This, in turn, may improve the outcomes for both the mother and the foetus in pregnancies that are affected by these interrelated disorders.
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