“Research on the "Engineering of Nano-gel for delivery of Mometasone and Itraconazole on Scalp and Beard for the Treatment of Fungal Infection"

Abstract

Scalp and beard fungal infection often treated with conventional dosage form like cream, gel, emul-gel, which causes various side effects, to overcome such problems this research was conducted to develop Itraconazole and Mometsone Anti-fungal Nano-Hydro- Gel that is effective in the treatment of fungal infections of the scalp and beard. Itraconazole belongs to Azole group, which inhibit Lanosterol 14 alfa demethylase, the enzyme that converts lanosterol to ergosterol. Ergosterol is a component of yeast and fungal membranes. Nano-formulation penetrates deeper into the skin. The gel formula retains its therapeutic effect as well as the soothing effect on the hair follicles for long time. Pre-formulation studies of Itraconazole and Mometasone particles were done, and then both the API particles were converted into nano- particles through solvent diffusion method. SEM, P-XRD, IR tests were performed for characterization of Nano-Particles. Nano- Hydrogel base, prepare by using Carbopol-940, Carbopol-934, Triethanolamine and Distilled Water and engineering done by adding drug. When both Carbopol grades (934 and 940) are used together in the formulation of gel, the drug will release over a longer period of time with a smaller dose and less chance of any dose-dependent harm.Various composition were engineered an evaluated for selection of model formulation.

Result- Evaluated for these parameters: Physical appearance, pH, estimation of practical yield, homogeneity, drug content uniformity, spreadability, viscosity, Statistical analysis of experimental data by ANOVA using Excel, In-vitro-drug release study, release kinetic study,

Particle size analysis, (SEM), FT-IR studies. In-Vitro Anti-fungal activity tested by using Nano-gel Franz diffusion cell (Make-Orchid scientific). Amount of drug released was determined using UV- spectrophotometer at 222 nm.

Conclusion- Fungal infection is most common skin condition occurs on the scalp and chin. Under these skin conditions, the hair follicles become inflamed and the affected area becomes itchy, flaky or scaly, causing redness, swelling and irritation. So this research was done with focus for pathology, pathogenesis consequently treatment of scalp and beard fungal infection