Effect Of Caulerpa Scalpelliformis Against Invasive Fungal Pathogens From Periyathalai Coastal Waters, Tuticorin District, Tamilnadu, India
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Abstract
Fungi cause diseases in a variety of marine animal hosts. The need for new antifungal agents arises from the rising prevalence of invasive fungal infections (IFI) and the ineffectiveness, severe side effects, and high mortality of the current antifungal agents. The present study aims to assess Caulerpa scalpelliformis seaweed extract's antifungal efficacy against human fungal infections. Using methanol solvents, the antifungal activity of marine macroalgae C.scalpelliformis was assessed against Candida albicans, Aspergillus fumigatus, Aspergillus niger, Aspergillus flavus, and Cryptococcus neoformans. C. scalpelliformis showed strong fungal activity against A. fumigatus, A. niger, and A. flavus compared to C. albicans and C. neoformans, similar to the positive control drug Amphotericin B in the current study.This is the first report from Tuticorin's Periyathalai coast. These results point to the use of green seaweed, C. scalpelliformis methanol extract as a natural antibiotic in conjunction with synthetic antibiotics, which has paved the way for the development of new anti-aspergillus, anti-cryptococcal, and anti-candidal compounds.
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References
Saidani K, Bedjou F, Benabdesselam F, Touati N. Antifungal activity of methanolic extracts of four Algerian marine algae species. African journal of biotechnology. 2012;11(39):9496-500.
Lin SJ, Schranz J, Teutsch SM. Aspergillosis case-fatality rate: systematic review of the literature. Clinical infectious diseases. 2001;32(3):358-66.
3.. Pourakbar L, Moghaddam SS, Enshasy HA, Sayyed RZ.Antifungal activity of the extract of a macroalgae, Gracilariopsis persica, against four plant pathogenic fungi. Plants. 2021;10(9):1781.
4.Groll AH, Shah PM, Mentzel C, Schneider M, Just-Nuebling G, Huebner K. Trends in the postmortem epidemiology of invasive fungal infections at a university hospital. Journal of infection. 1996;33(1):23-32.
Perez MJ, Falque E, Domínguez H. Antimicrobial action of compounds from marine seaweed. Marine drugs. 2016;14(3):52.
Raj GA, Chandrasekaran M, Krishnamoorthy S, Venkatesalu V. Antibacterial activity of different solvent extracts of Caulerpa chemnitzia (Esper) JV Lamououx, from Mandapam, Gulf of Mannar Southeast Coast, Tamil Nadu, India. Journal of Medicinal Herbs and Ethnomedicine. 2015;1(1):24-31.
Harada H, NoRo T, Kamei Y. Selective antitumor activity in vitro from marine algae from Japan coasts. Biological and Pharmaceutical Bulletin. 1997;20(5):541-6.
Mao SC, Guo YW, Shen X. Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia. Bioorganic & medicinal chemistry letters. 2006;16(11):2947-50.
Silva DL, Lima CM, Magalhães VC, Baltazar LM, Peres NT, Caligiorne RB, Moura AS, Fereguetti T, Martins JC, Rabelo LF, Abrahão JS. Fungal and bacterial coinfections increase mortality of severely ill COVID-19 patients. Journal of Hospital Infection. 2021;113:145-54.
Wingard JR, Kubilis P, Lee L, Yee G, White M, Louise W, Bowden R, Anaissie E, Hiemenz J, Lister J. Clinical significance of nephrotoxicity in patients treated with amphotericin B for suspected or proven aspergillosis. Clinical infectious diseases. 1999;29(6):1402-7.
Mayer FL, Wilson D, Hube B. Candida albicans pathogenicity mechanisms. Virulence. 2013;4(2):119-28.
Raj GA, Jegan S, Krishnamoorthy S, Chandrasekaran M, Venkatesalu V. Anticandidal and Antidermatophytic activities of Caulerpa species from the Gulf of Mannar Coast, Mandapam Tamilnadu India. International Journal of Pharmacology, Phytochemistry and Ethnomedicine. 2017;7:30-40.
Ismail A, Salah KBH, Ahmed M, Mastouri M, Bouraoui A, Aouni M. Antibacterial and antifungal activities of brown alga Zonaria tournefortii (JV Lamouroux). Allelopathy Journal. 2014;34: 143–153.
Taskin E, Caki, Z, Ozturk M, Taskin E. Assessment of in vitro antitumoral and antimicrobial activities of marine algae harvested from the eastern Mediterranean sea. African Journal of Biotechnology. 2010; 9: 4272–4277.
Manilal A,Sujith S, Selvin J, Kiran GS, Shakir C,Lipton AP. Antimicrobial potential of marine organisms collected from the southwest coast of India against multiresistant human and shrimp pathogens. Scientia Marina. 2010;74: 287–296.
Pinteus S,Alves C,Monteiro H, Araújo E, Horta A, Pedrosa R. Asparagopsis armata and Sphaerococcus coronopifolius as a natural source of antimicrobial compounds. World Journal of Microbiology and Biotechnology. 2015; 31: 445–451
17.Guedes EA, dos Santos Araujo MA, Souza AK, de Souza LI, de Barros LD, de Albuquerque Maranhao FC, Sant’Ana AE. Antifungal activities of different extracts of marine macroalgae against dermatophytes and Candida species. Mycopathologia. 2012;174:223-32.
18. Sugui J, Kwon-Chung K, Juvvadi P, Latge J, Steinbach W. Aspergillus fumigatus and related species. Cold Spring Harbor Perspectives in Medicine.2014;5:a019786.
19. Sasikala C, Geetha Ramani D. Comparative study on antimicrobial activity of seaweeds. Asian Journal of Pharmaceutical and Clinical Research.2017;10:384-6.
20. Karthick N, Fathimal MA, Ramesh K, Sridhar H, Natrajan M, Divya V, Umavanith M, Umamaheswari S. Screening of phytochemicals and antimicrobial activity of Caulerpa scalpelliformis collected from Manapad Coast, Tuticorin district, Tamilnadu, South India. Journal of Coastal Life Medicine. 2014;2(2):107-11.
21. Julyasih KS and Purnawati A. Antifungal Activity of Seaweed Against Aspergillus flavus. Nusantara Science and Technology Proceedings. 2019;19:11-3.
22. Lavanya R and Veerappan N. Pharmaceutical properties of marine macroalgal communities from Gulf of Mannar against human fungal pathogens. Asian Pacific Journal of Tropical Disease. 2012;2:S320-3.
23. Wefky S and Ghobrial M. Studies on the bioactivity of different solvents extracts of selected marine macroalgae against fish pathogens. Research Journal of Microbiology.2008; 3: 673-682.
24. Kim KH, Eom SH, Kim HJ, Lee DS, Nshimiyumukiza O, Kim D, Kim YM, Lee MS. Antifungal and synergistic effects of an ethyl acetate extract of the edible brown seaweed Eisenia bicyclis against Candida species. Fisheries and aquatic sciences. 2014;17(2):209-14.
25. Khallil AM, Daghman IM, Fady AA. Antifungal potential in crude extracts of five selected brown seaweeds collected from the Western Libya Coast.Journal of Microbiology and Modern Techniques. 2015;1: 1-8.
26. Singh O and Ali M. Phytochemical and antifungal profiles of the seeds of Carica papaya L. Indian Journal of Pharmaceutical Sciences. 2011;73(4):447.
27. Manivannan K, Anantharaman P, Balasubramanian T. Antimicrobial potential of selected brown seaweeds from Vedalai coastal waters, Gulf of Mannar. Asian Pacific journal of tropical biomedicine. 2011;1(2):114-20.
28. Manigandan M and Kolanjinathan K. In vitro antifungal activity of certain seaweeds collected from Mandapam coast, Tamilnadu, India. International Journal of Advanced Research in Biological Sciences. 2014;1(7):557-9.
29. Hartsel SC and Weiland TR. Amphotericin B binds to amyloid fibrils and delays their formation: a therapeutic mechanism?.Biochemistry.2003;42(20):6228-33.