The Role Of Herbal Drugs For The Management Of Fungal Skin Diseases: A Review
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Abstract
The goal of the study was to formulate a cream with a composition for treating fungal skin infections and which enhances skin properties. This formulation belongs to a medicinal cream that has two antifungal active components. It reveals a formula for treating fungal skin infections, as well as other components that can help improve skin issues. For skin infections, the topical approach is the best option. Because of the numerous advantages over traditional routes of drug administration, the development of topical drug delivery systems with systemic effects appears to be advantageous for a variety of medications. Garlic oil and clove oil are the active pharmaceutical ingredients (API) used to treat fungal skin infections. It also includes two types of primary and secondary emulsifiers waxy materials, co-solvents, two preservatives, a buffering agent, a humectants, and water in the cream base. When the active components are combined, they provide a potent antifungal effect. Several experiments were done to assess the physicochemical characteristics of formulated cream, such as visual inspection, pH measurement, extrudability, expandability, skin irritant test, etc. The cream was further analyzed with the use of nutritional agar for antifungal activity. The medicated cream was good in consistency and color; however the smell of the garlic was quite unpleasant, so the odor of the garlic was masked with peppermint oil, which also acting as an additional antifungal agent, in improved version.
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References
Crawford, F.Athlete’sfoot. BMJ Clinical Evidence, July20, 2009:1712.
C.k. Kokate; A.P Purohit; S.B. Gokhale; Textbook Of Pharmacognocy; Nirali Prakashan; 15th Edition; Sept., 2014; 16.67-16.68.
Deosarkar S.S; Khedkar C.D; Kalyankar S.D; Sarode A.R; The Encyclopedia Of food And Health, Volume-2, Oxford Academic Press, 2016; 331-332.
More B.H; Sakharwad S.N; Tembhurne S.V; Sakarkar D.M; Evalution For Skin Irritacy Testing Of Developed Formulations Containing Tulsi Oil For Its Topical Application, International Journal Of Toxicology And Pharmacology, 2013; 10-13.
Parmar P.B; Baria A.H; Faldu S.D; Tank H.M; Design And Evaluation Of Herbal Formulation In Semisolid Dosage Form Journal Of Pharmacy Research, 2009; 1095-1097.
V.V Paithankar, Formulation And Evaluation Of Herbal Cosmetic Preparation Using Safed Musli, International Journal Of Pharma Tech Research, 2010.
Babu Novel Herbal Composition For Treatment of Skin Dissorder U.S. patentU.S.,2011; 0165136.
Note For Guidence On Stability Testing Stability, Stability Testing Of New Drug Substance And Product.
Bronaugh R.L and Naibach H.I; “Topical Absorption of Dermatogical Product” Mercel Dekk.
Sumathi A; Senthamari R.; AReviewon Harbal Medicines and Drug TechnologyAsia.J. Pharm. Health Science, 2015; 1172-1173.
Osborne, D.W, Review of Changes In Topical Drug Classification. Pharm. Tech., 2008; 32: 66-74.
Mali AS, Karekar P, Yadav A.V, Formulation and Evaluation of Multipurpose Herbal Cream, International Journal of Science and Research, International Journal of Science and Research, 2015; 4 (11):1495-1498.
Kapoor S, Saraf S, Formulation and Evaluation of Moisturizer Containing Herbal Extracts for the Management of Dry Skin, Pharmacognosy Journal, 2010; 2(11):409-418.
Efterpi V. Christaki and Panagiota C. Florou-Paneri,Aloe- Vera : A plant for many use, Journal of Food, Agriculture & Environment, 2010; 8 (2):245-249.
Vinchure BD., Kokate R and Patil SP., Formulation And Evaluation Of Cream Containing Curcumin And Lycopene For The Antioxidant And Antibacterial Activity., European Journal Of Pharmaceutical And Medical Research, 2017; 4(05):394-399.
Bhowmik D, Yadav CJ, Tripathi K. K., Sampath K.P., Herbal Remedies of Azadirachta indica and its Medicinal Application, Journal of Chemical and Pharmaceutical Research, 2010; 2(1):62-72.
Mehta R.M., Pharmaceutics-I,6th Edition, 2018, Vallabh Prakashan, Delhi ,55-59.
Gupta N, Dubey A, Prasad P, Roy A, Formulation and Evaluation of Herbal Fairness Cream Comprising Hydroalcoholic Extracts of Pleurotus ostreatus, Glycyrrhiza glabra and Camellia sinensis, UK Journal of Pharmaceutical and Bioscience, 2015; 3(3):40-45.
Mishra AP, Saklani S, Milella L, Tiwari P, Formulation and evaluation of herbal antioxidant face cream of Nardostachys jatamansi collected from Indian Himalayan region, Asian Pacific Journal of Tropical Biomedicine, Asian Pacific Journal of Tropical Biomedicine 2014; 4(2): S679-S682
Shubhangi E. Sawant, Monali D. Tajane, Formulation and evaluation of herbal ointment containing Neem and Turmeric extract, Journal of Scientific and Innovative Research 2016; 5(4):149-151.
Ebru Altuntaş and Gülgün Yener, Anti-aging potential of a cream containing herbal oils and honey: Formulation and in vivo evaluation of effectiveness using noninvasive biophysical techniques, IOSR Journal of Pharmacy and Biological Sciences, 10(6), 2015, 51-60.
Singh Mandeep, Sharma Shalini, Khokra Sukhbir Lal, Sahu Ram Kumar, Jangde Rajendra, Preparation And Evaluation Of Herbal Cosmetic Cream, Pharmacologyonline 2,2011: 1258-1264.
Alemdar S, Agaoglu S. Investigation of In vitro Antimicrobial activity of Aloe vera juice. Journal of Animal and Veterinary Advances 2009: 8(1): 99-102.
Koka S, Pancholi M, Sharma V. Formulation and Evaluation of Topical Antifungal Herbal Gels Containing Hydroalcoholic Extract of Catharanthus roseus and Aloevera International Journal of Pharmacognosy and Phytochemical Research 2019; 11(3);173-176.
Hugo WB, Russell AD: Pharmaceutical Microbiology: Blackwell Science, 6 Ed, 2003; 35-51
Khan Z K, Gyanchandani A, Candidiasis A Review: PINSA: 1998: B 64 :1-34
Baqars S R, The role of traditional medicine in the real environment, Traditional Medicine in Africa I ssaq, East African Education Publisher LTD, Nairobi, 1995 p 141-142.
Pimpale A, Formulation and Evaluation of Antibacterial Antifungal Cream of Garlic Oil, International Journal of Trend in Scientific Research and Development (IJTSRD), No:2456-6470|Volume-3| Issue–1|Nov–Dec2018.