Predictive Value of CRP and Lactate Levels for Bowel Gangrene/Strangulation in Patients with Bowel Obstruction

Abstract

Background: Bowel blockage is a frequent and potentially fatal illness that requires quick identification of consequences like gangrene and strangling of the bowel. In order to diagnose intestinal gangrene/strangulation in patients with bowel obstruction, this study evaluated clinical symptoms and laboratory markers, specifically C-reactive protein (CRP) and lactate levels. Methods: One hundred patients who presented with intestinal obstruction participated in prospective observational research that we conducted. Clinical signs were evaluated, including guarding, vomiting, abdominal distension, irreducible edema, and pain in the abdomen. For the purposes of measuring lactate and CRP, blood samples were taken. Radiological findings, intraoperative assessment, and histological examination were required as part of the diagnostic criteria for intestinal gangrene/strangulation. Results: Common clinical symptoms were stomach discomfort (98%), vomiting (67%), and abdominal distension (58%). In 40% of individuals, irreversible edema was observed. In 54% of instances, a history of constipation was mentioned. Gangrenous bowel was substantially related with elevated lactate and CRP levels (p 0.001). In gangrenous bowel, mean lactate concentrations were 870.25 mmol/L compared to 536.62 mmol/L in viable bowel, and mean CRP concentrations were 141 mg/L compared to 68.23 mg/L in viable intestine. Conclusion: Bowel blockage is typically diagnosed based on clinical signs such abdominal pain and unremitting swelling. Furthermore, in these individuals, high CRP and lactate levels are useful indicators for detecting intestinal gangrene/strangulation. The incorporation of these markers into clinical practice may help patients with intestinal obstruction receive early management and experience better results. To determine precise cutoff values for these markers in everyday practice, more study is required.