Role of Citrus Concentrate in Extraction and Evaluation of Herbal Polymer

Abstract

Background: The use of natural polymers as excipients in the pharmaceutical sector is expanding day by day. Low cost, safety issues, availability, and biodegradability are the main causes that make them differ from other sources. Natural sources have a wide range of varieties and characteristics. So, they can be used numerous times in pharmaceutical products as excipients to serve the desired purposes.  Aim:  To extract and evaluate the natural polymeric substances that can be used as excipients in pharmaceuticals from fenugreek seeds by using solvent extraction method. Methods: Trigonella foenum-graceum fenugreek mucilage is drive from the endosperm of the seeds it consists of galactose and mannose of it gives high viscosity in aqueous solution the fenugreek seeds used for thickening, stabilizing and emulsifying food agent. In this procedure we use grapefruit juice to treat with extract mucilage from fenugreek seeds which enhance its stability and bioavailability. Grapefruit juice increases the bioavailability of some orally administered drugs that are metabolized by CYP3A4 and normally undergo extensive presystemic extraction. Results: In addition, grapefruit juice it can decrease the oral absorption of a few drugs that rely on organic anion transporting polypeptide in the gastrointestinal tract for their uptake. The number of drugs shown to interact with grapefruit juice in vitro is far greater than the number of clinically relevant grapefruit juice drug interactions.