Histological Changes Of Kidney, Liver, Pancreas In Alloxan Induced Diabetic Mice Treated With Selenicereus Undatus (Haw). Ethanolic Extract
DOI:
https://doi.org/10.53555/jaz.v46i1.5098Keywords:
Diabetes, Alloxan, Selencereus undatus, Epicarp, EndomesocarpAbstract
Forty-eight swiss albino mice, weighing between 25-30 grams were used in this
experiment. There are a total of six mice in each group and each group was divided into eight
equal sections. Diabetes was induced in group 2,3,4,5,6,7 using alloxan monohydrate of (150
mg/kg body weight) administered intraperitoneally to overnight fasted animals. Group 1:-
Served as the control. Group 2:- Mice induced with diabetes .Group 3:- Diabetic induced
mice treated with metformin of 75 mg /kg body weight. Group 4:- Diabetic induced mice
treated with Epicarp 45 mg/kg body weight. Group 5:- Diabetic mice treated with Epicarp of
75 mg/kg body weight. Group 6:-Diabetic induced mice treated with Endo mesocarp of 45
mg/kg body weight. Group 7:-Diabetic mice treated with Endo mesocarp of 75 mg/g body
weight. Treatments were administered via orogastric intubation for 27 days. All animals had
free access to pellet feed and water throughout the experiment. On the 28th day, the animals
were sacrificed, and the peritoneium was opened to collect the pancreas, kidneys, and liver,
which were preserved in 10% formaldehyde for histological observation using the
haematoxyline and eosin staining technique. Histological analysis showed regenerative
changes in pancreas, liver, kidney of mice treated with epicarp of 45 mg/kg body weight and
endo mesocarp of 75 mg/kg body weight.
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