Development And Evaluation Of Microwave Generated Nanocomposites For Solubility Enhancement Of Orlistat Drug

Abstract

The development of a technique for lowering the particle size and turning the drug into an amorphous state can increase the solubility and bioavailability of BCS Class II medications like Orlistat. A promising method for oral delivery of medications with low solubility is to create nanocomposites (NCs) utilising natural carriers. For the purpose of improving the solubility of the weakly water soluble (BCS class II) model drug Orlistat, nanocomposites were created in the current study utilising the microwave induced diffusion technique (MIDT). Due to its limited water solubility and its oral bioavailability, it is extremely low. The natural carrier’s Acacia, Xanthum gum, Gelatin powder, Chitosan, and Tragacanth were used to create the nanocomposites of orlistat. With different concentrations of medication and carriers, various physical mixture and nanocomposites formulations were created. Natural carriers were chosen based on their surfactant and wetting characteristics.  According to the dissolving analysis of the optimised nanocomposites IR tablet, the dissolution rates were noticeably better in NCs IR tablet as compared to the marketed tablet. Out of four tablet formulations, tablet F2 had the shortest disintegration time, so it was chosen for further examination and an in-vitro dissolving test was carried out to see whether the tablet was releasing the medicine. The amount of medication released after 30 minutes was determined to be 91.45 ± 1.2 % as opposed to the 75.65 ± 1.3 % shown on the commercial tablet.  Fourier transform infrared spectroscopy, Differential scanning calorimetry, X-ray diffraction, and Scanning electron microscopy were used to characterise the optimised nanocomposites. The nanocomposites OGAN4 (Orlistat + Acacia gum powder) formulation was shown to be optimal in terms of solubility enhancement of a drug by microwave assisted synthesis based on solubility, in-vitro drug release, and physical characterization of carriers. The MID technique used in this work remains environmentally friendly, inexpensive, then a possible technique aimed at improving solubility.