Formulation Development & Invitro Evaluation Of Felbamate Nanosuspensions By Using Anti Solvent Precipitation And Ultrasonic Method

Authors

  • Marabathuni V Jhansi Priya
  • Chennu M M Prasada Rao

DOI:

https://doi.org/10.53555/jaz.v45i3.4350

Keywords:

Felbamate, dispersity index, Zeta potential, Kinetic studies

Abstract

Abstract

 

The Felbamate nanosuspension formulation was prepared by using the anti-solvent precipitation and ultrasonic method. In this work the polymers like HPMC K4M, Poloxamer 188.Polyvinyl alcohol, Polyethylene Glycol 400, as anti-solvent acetone was used. total eight formulations were prepared by using different composition of the polymers based on the prepared formulations (F1 – F8) were evaluated for Drug content, Solubility determination, In vitro drug release study, ATR-FTIR spectroscopy, Particle size determination and poly dispersity index, Zeta potential determination and Morphology characterization by scanning electron microscopy. All the formulations were evaluated for drug content which was in the range 90.15 & to 98.95 %The solubility determination of all formulations in phosphate buffer pH 6.8 was found to be in the range of 0.0156 mg/ml to 0.0375 mg/ml. The results showed that the solubility of formulation was found to be higher in F1 (0.031 mg/ml) compared with other formulations. The solubility of all formulations improved (from insoluble to slightly soluble) compared to pure drug of Felbamate. The in vitro release was carried out for all formulations. The results showed that as the concentration of polymer was increased, the percentage drug release was decreased. Optimized formulations showed 98.69% and 96.49% drug release within 120 minutes, but pure drug released upto 22.46% only. The release rate kinetic data for the best as a F1 formulation showed that the formulation provided good linearity was observed with the zero order (R2 = 0.9), the zero-order kinetics explains the good release of the prepared nanosuspension over the period of 120 minutes. The data were fitted into the Korsmeyer-Peppas equation which showed good linearity and the slope of the Korsmeyer-Peppas plot (n= 0.969) were found to be more than 0.45 indicating the diffusion mechanism is Case II transport

Downloads

Download data is not yet available.

Author Biographies

Marabathuni V Jhansi Priya

Research Scholar, School of Pharmacy, Raffles university, Neemrana- 301705.

Chennu M M Prasada Rao

Professor, School of Pharmacy, Raffles University, Neemrana- 301705

References

Jain KK. In: Methods in Molecular Biology: Drug Delivery Systems - An Overview. Totowa, NJ: Humana Press; 2008. p. 1–50.

Thassu D, Deleers M, Pathak Y. Nanoparticulate Drug Delivery Systems. Drug Dev Ind Pharm. 2007;34(1):352.

Brahmankar D, Jaiswal S. Biopharmaceutics and Pharmacokinetics- A treatise. Second edition. New Delhi: Vallabh Prakashan; 2009. 400–443 p.

Tiwari G, Tiwari R, Bannerjee S, Bhati L, Pandey S, Pandey P, et al. Drug delivery systems: An updated review. Int J Pharm Investig. 2012;2(1):2.

Remington. The science and practice of pharmacy. 21st ed. New Mexico: Pharmaceutical Press; 2001. 939–964 p.

National Center for Biotechnology Information. PubChem Compound Summary for CID 3331, Felbamate. https://pubchem.ncbi.nlm.nih.gov/compound/Felbamate. Accessed Mar. 9, 2024.

Anees M, Masood MI, Ilyas M, Ammad M. Nanoparticles as a Novel Drug Delivery System: A Review. Pak J Pharm Res. 2016 Jul 15;2(2):160–167.

Morrow KJ, Bawa R, Wei C. Recent Advances in Basic and Clinical Nanomedicine. Med Clin North Am. 2007 Sep 1;91(5):805–843.

Sahoo SK, Parveen S, Panda JJ. The present and future of nanotechnology in human health care. Nanomedicine Nanotechnol Biol Med. 2007 Mar;3(1):20–31.

Ramsden JJ. Chapter 1 - What is Nanotechnology? In: Nanotechnology. Oxford: William Andrew Publishing; 2011. p. 1–14.

Patravale VB, Date AA, Kulkarni RM. Nanosuspensions: A promising drug delivery strategy. J Pharm Pharmacol. 2004 Jul;56(7):827–840.

Konwarh R, Gogoi B, Philip R, Laskar MA, Karak N. Biomimetic preparation of polymer-supported free radical scavenging, cytocompatible and antimicrobial “green” silver nanoparticles using aqueous extract of Citrus sinensis peel. Colloids Surf B Biointerfaces. 2011;84(2):338–345.

Hnawate R, Deore P. Nanoparticle - novel drug delivery system: A Review. Pharma Tutor. 2017;5(5):9–23.

Chan VSW. Nanomedicine: An unresolved regulatory issue. Regul Toxicol Pharmacol RTP. 2006 Dec;46(3):218–224.

Freitas RA. What is nanomedicine? Nanomedicine Nanotechnol Biol Med. 2005 in Pharmacy. Int J Pharm Sci Nanotechnol. 2014 Aug 31;7(3):2509–2519.

Marabathuni VJ, Dinesh P, Ravikumar R, Yamini P, Kiran PS, Hussain SP, Rao CM. Chitosan based sustained release mucoadhesive buccal patches containing amlodipine besylate (AMB). Asian Journal of Research in Pharmaceutical Science. 2017;7(2):97-104.

Mudshinge SR, Deore AB, Patil S, Bhalgat CM. Nanoparticles: Emerging carriers for drug delivery. Saudi Pharm J SPJ. 2011 Jul;19(3):129–41.

Marabathuni VJ, Bhavani M, Lavanya M, Padmaja K, Madhavi N, Babu P, Rao CM. Formulation and evaluation of mouth dissolving Tablets of carbamazepine. Asian Journal of Pharmacy and Technology. 2017;7(3):137-43.

Maravajhala V, Papishetty S, Bandlapalli S. Nanotechnology in Development of Drug Delivery System. Int J Pharm Sci Res. 2012 Jan 1;3(1):84–96.

MVJ Priya, CMMP Rao” Formulation Development and Invitro Evaluation Of Stiripentol Nanosuspension By Solvent Evaporation Method “Eur. Chem. Bull. 2023, 12(Special Issue 5), 1739 – 1750

Tadros T. Encyclopedia of Colloid and Interface Science. Berlin, Heidelberg: Springer Berlin Heidelberg; 2013. 748–781 p.

Downloads

Published

2024-03-13

Issue

Section

Articles

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.