Formulation Development & Invitro Evaluation Of Felbamate Nanosuspensions By Using Anti Solvent Precipitation And Ultrasonic Method
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Abstract
Abstract
The Felbamate nanosuspension formulation was prepared by using the anti-solvent precipitation and ultrasonic method. In this work the polymers like HPMC K4M, Poloxamer 188.Polyvinyl alcohol, Polyethylene Glycol 400, as anti-solvent acetone was used. total eight formulations were prepared by using different composition of the polymers based on the prepared formulations (F1 – F8) were evaluated for Drug content, Solubility determination, In vitro drug release study, ATR-FTIR spectroscopy, Particle size determination and poly dispersity index, Zeta potential determination and Morphology characterization by scanning electron microscopy. All the formulations were evaluated for drug content which was in the range 90.15 & to 98.95 %The solubility determination of all formulations in phosphate buffer pH 6.8 was found to be in the range of 0.0156 mg/ml to 0.0375 mg/ml. The results showed that the solubility of formulation was found to be higher in F1 (0.031 mg/ml) compared with other formulations. The solubility of all formulations improved (from insoluble to slightly soluble) compared to pure drug of Felbamate. The in vitro release was carried out for all formulations. The results showed that as the concentration of polymer was increased, the percentage drug release was decreased. Optimized formulations showed 98.69% and 96.49% drug release within 120 minutes, but pure drug released upto 22.46% only. The release rate kinetic data for the best as a F1 formulation showed that the formulation provided good linearity was observed with the zero order (R2 = 0.9), the zero-order kinetics explains the good release of the prepared nanosuspension over the period of 120 minutes. The data were fitted into the Korsmeyer-Peppas equation which showed good linearity and the slope of the Korsmeyer-Peppas plot (n= 0.969) were found to be more than 0.45 indicating the diffusion mechanism is Case II transport
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