Preparation And Evaluation Of Microwave Generated Nanobiocomposite For Solubility Enhancement Of Naproxen And Its Prepared Gel For Anti- Inflammatory Activity
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Abstract
Naproxen is an NSAID, or non-steroidal anti-inflammatory medicine. The creation of an oral dosage form for naproxen, which is a member of BCS class II and has a low solubility, has proven difficult. A cutting-edge method for improving solubility is nanocomposite creation. For the creation of nanocomposites, microwaves were used. Nanocomposites were created using polymers such as HPMC, tragacanth, acacia, and avicel as carriers. HPMC and tragacanth were employed for additional research after the physical characterization of polymers, such as their foaming index, viscosity, and swelling index. Eight distinct formulations were made using varied dosages of medication and carrier, and equivalent physical combinations were also made. From many nanocomposites’ formulations, NTHN (1:4) and NTTN (1:4) demonstrated good solubility and were the best ratios. Compared to pure naproxen, which demonstrated a dissolution of 49.32 % in an in-vitro drug release study, the medication disintegrated 86.73%. Numerous characteristics, including FTIR, DSC, and SEM, were examined for the prepared nanocomposites. In-vitro drug release, appearance, or drug content of the nanocomposites did not alter significantly over the course of a three-month stability trial. According to the overall findings, Naproxen's solubility can be increased by using microwave aided nanocomposites formulation.
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