Therapeutic Potential Of Benincasa Hispida For The Treatment Of Alzheimer Disease
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Abstract
This article provides details on the annual climbing plant Benincasa hispida, a natural herb from the cucurbitaceae family.. The fruit is also called as winter gourd, ash gourd and kushmanda fruit. It is the most well-liked herb that is readily available to communities for medicinal and nutritional purposes. The phytochemical review indicates the presence of pentacyclic triterpene, flavonoids, volatile oils, bryonolic acid, alnusenol, multiflorenol, isomultiflorenol, lupeol, β-sitosterol etc. Benincasa hispida fruit is one of incredible fruit which can improve health, treat a variety of illnesses and prevent many more. Pharmacological studies have revealed that the Benincasa hispida plant is useful in the treatment of several nerve diseases, including peptic ulcer, diabetic mellitus, internal organ hemorrhages, jaundice, epilepsy, and Alzheimer's disease.. The review mainly focuses on the effect of the fruit Benincasa hispida's potential to treat alzheimer's disease.This article covers all relevant information regarding Benincasa hispida with both historical and contemporary examples
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References
Grover, J., et al., Extracts of Benincasa hispida prevent development of experimental ulcers. Journal of ethnopharmacology, 2001. 78(2-3): p. 159-164.
Al-Snafi, A.E., The Pharmacological Importance of Benincasa Hispida. International Journal of Pharma Sciences and Research, 2013. Vol 4 No 12 Dec 2013.
Neha Ayubkhan*, D.M.G., Dr Lincy Joseph, Dr K.Sujith, . International Journal of Pharmaceutical and Biological Science, 2019. 2(2): p. 263-266.
Doharey, V., et al., Pharmacognostical, physicochemical and pharmaceutical paradigm of ash gourd, Benincasa hispida (Thunb.) fruit. Plant Archives, 2021. 21(1): p. 249-252.
Chakraborty, a.d.a.s., kushmanda (benincasa hispida): an amazing food in ayurveda. World Journal of Pharmaceutical Research, 2020. 9(15, 2020.).
Zaini, N.A.M., et al., Kundur [Benincasa hispida (Thunb.) Cogn.]: A potential source for valuable nutrients and functional foods. Food Research International, 2011. 44(7): p. 2368-2376.
N.S. Gill, K.D., J. Bajwa, P. Sharma and S. Sood Rayat, Evaluation of Free Radical Scavenging, Anti-inflammatory and Analgesic Potential of Benincasa hispida Seed Extract. Intemational Joumal of Pharmacology, 2010. 6 (5): : p. 652-657.
Lim, T. and T. Lim, Benincasa hispida cv-gr. Wax Gourd. Edible Medicinal And Non-Medicinal Plants: Volume 2, Fruits, 2012: p. 167-178.
Samad, N.B., et al., Antioxidant activity of Benincasa hispida seeds. Journal of Food Biochemistry, 2013. 37(4): p. 388-395.
Ambikar, D.B. and G.P. Mohanta, Neuroprotective Effect of Petroleum Ether, Methanolic and Aqueous Extracts of Fruits of Benincasa hispida on Lipofuscinogenesis and Fluorescence Product in Brain of D-galactose Induced Aging Accelerated Mice. Indian Journal of Pharmaceutical Education and Research, 2021. 55(2s): p. s528-s534.
Alsaadi, S.A.R.A. and K.S. Abass, Benincasa hispida is an antioxidant of possible physiological importance: A comparative review. Plant Archives, 2020. 20(2): p. 2833-2838.
Dhingra, D. and P. Joshi, Antidepressant-like activity of Benincasa hispida fruits in mice: Possible involvement of monoaminergic and GABAergic systems. J Pharmacol Pharmacother, 2012. 3(1): p. 60-2.
Roy, C. and D. Guha, Role of Benincasa hispida linn. on brain electrical activity in colchicine induced experimental rat model of alzheimer’s disease: Possible involvements of antioxidants. World J. Pharm. Res, 2017. 6: p. 1439-1443.
Jayasree Tirumalasetty, C.N.a.A.N., Evaluation of diuretic activity of ethanol extract of Benincasa hispida stem in swiss albino rats Journal of Chemical and Pharmaceutical Research, 2013. 5(3)(91-97).
Parida, N., et al., Antinociceptive and antiinflammatory effects of methanolic extract of Benincasa hispida fruit peel in rodents. Asian Journal of Chemistry, 2010. 22(10): p. 7573-7579.
Reichert, J.M. and J.B. Wenger, Development trends for new cancer therapeutics and vaccines. Drug Discov Today, 2008. 13(1-2): p. 30-7.
Soliman, W.E., et al., Therapeutic Applications of Biostable Silver Nanoparticles Synthesized Using Peel Extract of Benincasa hispida: Antibacterial and Anticancer Activities. Nanomaterials (Basel), 2020. 10(10).
H, S.D.S., Clinical Significance of Drinking Ash Gourd Juice: A Review Article. Nutrition and Food Sciences Research, 2022. Vol 9(4): p. 11-17.
Vrushabendra swamy bhyrapur mathad, s.c., Sreenivasa rao thirumala setty, Dhanapal ramaiyan, balamuralidhar veeranna, ashoka babu vechham lakshminarayanasettry, Antidiarrheal Evaluation of Benincasa hispida Thun., Iranian journal of pharmacology & therapeutics, 2005. 4: p. 24-27.
S. Chandra Babu1*, R.I., M. A. C. Sahib Thambi Refai2, L. H. Thameemul - Ansari2, D. Anil Kumar2, Preliminary pharmacological screening of Benincasa hispida Cogn. 2002. Vol. 3/2 (2003) p. 143 - 147.
Du, Q., et al., Di-2-ethylhexyl phthalate in the fruits of Benincasa hispida. Food additives and contaminants, 2006. 23(6): p. 552-555.
Qadrie, Z.L., et al., Antinociceptive and anti-pyretic activity of Benincasa hispida (thunb.) cogn. in Wistar albino rats. Pakistan Journal of Pharmaceutical Sciences, 2009. 22(3).
Abubakar, M.B., et al., Alzheimer's Disease: An Update and Insights Into Pathophysiology. Front Aging Neurosci, 2022. 14: p. 742408.
Rapaka, D., et al., Benincasa hispida alleviates amyloid pathology by inhibition of Keap1/Nrf2-axis: Emphasis on oxidative and inflammatory stress involved in Alzheimer's disease model. Neuropeptides, 2021. 88: p. 102151.
Anbarasu, U., K. Jayagowri, and K. Bhuvaneswari, Effect of Benincasa hispida Fruit Dry Powder on Behaviour Changes and Antioxidants Levels in Adult Wistar Rats: An Experimental Study. Journal of Clinical & Diagnostic Research, 2022. 16(11).
Roy, C., T.K. Ghosh, and D. Guha, Dose Dependent Activity of Benincasa hispida on Colchicine Induced Experimental Rat Model of Alzheimer`s Disease. International Journal of Pharmacology, 2008. 4(4): p. 237-244.
Roy, C. and D. Mazumdar, A nootropic effect of Benincasa hispida on Ach and ChAT activity in colchicine induced experimental rat model of Alzheimer’s disease: Possible involvement of antioxidants. World Journal of Pharmaceutical Research, 2014. 3(9): p. 1282-1296.