“Design, Synthesis, And Characterization Of Novel Benzimidazole Derivatives And Their Biological Evaluation”

Abstract

Because of their various biological functions and possible therapeutic uses, benzimidazole derivatives have drawn a lot of interest in medicinal chemistry. Our goal was to create, manufacture, and assess a number of new benzimidazole derivatives with improved pharmacological properties in this work. In order to maximize target interactions with particular biological targets, the benzimidazole scaffold was logically modified during the design process. A multistep synthetic process was used to create the novel derivatives, allowing for the integration of various functional groups. The effective synthesis of the intended chemicals was confirmed by characterizing techniques such nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and infrared spectroscopy. The produced compounds were then evaluated using an in vitro techniques. Human cell lines were used in preliminary cytotoxicity tests to get knowledge about the derivatives' possible safety characteristics. This study's findings identified a number of benzimidazole compounds with significant biological properties and possible medicinal uses. In conclusion, a number of substances with remarkable therapeutic potential have been produced as a result of the design, synthesis, and assessment of novel benzimidazole derivatives.