Heteroarylpyrimidine Ring As An Anticancer Agent: A Review
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Abstract
Background: Cancer is a broad collection of illnesses that can begin in practically any organ or tissue of the body. These illnesses are brought on when abnormal cells grow out of control, cross their normal boundaries to infect nearby body parts and/or spread to other organs. The latter process, known as metastasizing, is a significant contributor to cancer-related mortality.
Main text: The Heteroarylpyrimidine ring system has garnered significant interest in medicinal chemistry due to its potential as an anticancer agent. In the past several years, a large number of brand-new pyrimidine derivatives have been created and studied for their anticancer activities. The current review attempts to concentrate on the relationship between pyrimidine derivatives structure and activity in relation to biological response as an anticancer agent throughout the past ten years.
Conclusion: This review aims to aid in the creation of pyrimidine scaffold-based anticancer medications that are more effective and potent. This review article discusses the 4-heteroarylpyrimidine ring's reported anticancer activity on a variety of cancer cell lines. This review aims to provide an overview of the recent advancements and studies regarding the use of this ring system in anticancer drug development
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