Exploring the Antimicrobial Potential of Phyllanthus emblica L. (Amla) using Molecular Docking Studies against Shrimp Pathogens

Authors

  • Mariam Ali Kki Mohamed Ali Department of Biotechnology, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, India
  • Prakash B Department of Biotechnology, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, India
  • Ling Shing Wong Faculty of Health and Life Sciences, INTI International University, Persiaran Perdana BBN, Nilai 71800, Negeri Sembilan, Malaysia
  • Kumar Krishnan Faculty of Health and Life Sciences, INTI International University, Persiaran Perdana BBN, Nilai 71800, Negeri Sembilan, Malaysia
  • Durgadevi Ravindran Department of Biotechnology, Vels Institute of Science Technology & Advanced Studies, Chennai, Tamilnadu, India.
  • Sowmiya Hari Department of Bio Engineering, School of Engineering, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, India
  • Ashok Kumar K Department of Biotechnology, Vels Institute of Science Technology & Advanced Studies, Chennai, Tamilnadu, India.
  • Jayanthi M Department of Biotechnology, Vels Institute of Science Technology & Advanced Studies, Chennai, Tamilnadu, India.
  • Suganthi M Department of Biotechnology, Vels Institute of Science Technology & Advanced Studies, Chennai, Tamilnadu, India.
  • J.Manjunathan Department of Biotechnology, Vels Institute of Science Technology & Advanced Studies, Chennai, Tamilnadu, India.
  • Abirami G Department of Biotechnology, Vels Institute of Science Technology & Advanced Studies, Chennai, Tamilnadu, India.

DOI:

https://doi.org/10.17762/jaz.v44i4.1865

Keywords:

Vibriosis, Shrimp, Phyllanthus Emblica, Phytochemical Analysis, Dockin

Abstract

Vibriosis is a major problem in shrimp farm. Farmers indiscriminately use hormones, antibiotics, disinfectants and other chemicals in fish feed and culture water to protect their crops. E. coli and Aeromonas sp were highly predominant isolates. Herbs act as agents in aquaculture to control or reduce pathogen infections. The results of phytochemicals screening of fruit extract of Phyllanthus emblica showed the presence of various phytchemicals. Phyllanthus emblica extract shows anti-bacterial properties against biofilm producing shrimp pathogens. Among the 10 bacterial genera, E. coli and P.aeruginosa were highly suppressed. The extracts exhibited the bacteria growth inhibitory activity in a dose-dependent manner. The compound sitosterol has potent antibiofilm activity was showed by molecular docking, which revealed a significant binding energy and interaction (-8.4 Kcal/mol) between it and key biofilm-forming protein. Diving analysis was done using the chemical compounds found in GCMS analysis.

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Published

2023-11-20

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