Formulation and evaluation of dental gel of Curcuma longa and Phyllanthus emblica loaded Silica nanocomposite as dental plaque inhibitor
DOI:
https://doi.org/10.53555/jaz.v43i1.5149Keywords:
Dental plaque, dental gel, antibacterial, anti-plaque, Phyllanthus emblica, Curcuma longaAbstract
The current research aimed to formulate a dental gel with an antibacterial action against Streptococcus mutans (the predominant cause of dental plaques) and a gel with antiplaque action by dissolution of plaque dextran. Ethanolic extracts of two medicinal plants Phyllanthus emblica and Curcuma longa were prepared and loaded onto silica nanoparticles synthesized from rice husk to obtain a silica-plant extract nanocomposite. The latter was analysed for their antibacterial action against Streptococcus mutans by agar well diffusion methods and plaque dissolution properties by phenol sulphuric acid methods in vitro. Finally, a dental gel with antibacterial and antiplaque effects was formulated using the above plant extracts, silica nanoparticles, and chitosan as key ingredients. The zone of inhibition of different components of the formulated gel indicated that individual components of Curcuma longa, and Phyllanthus emblica gave promising antibacterial activity against Streptococcus mutans as compared to the chloramphenicol and an increase in antibacterial role was observed in the extract combinations, with silica nanoparticle-loaded extracts giving the best activity. The percentage of dissolution of dextran was found to be higher in the silica-incorporated dental formulation, and the release of dextran was found to increase in a time-dependent manner of 70.321 mg% at 15 minutes. The formulation was noted for its antibacterial, plaque dissolution and ideal gel properties to be a suitable dental gel for plaque control. To our knowledge, this is the first report on a dental formulation gel with both antibacterial and plaque dissolution properties.
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Copyright (c) 2022 Snigdha S Babu, Sharrel Rebello, Ramesh S, Vinod Kumar, Rishad K.S, K.L .Krishna Kumar
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