Histochemical Indicators of The Adrenal Glass Under Acute Exposure to Magnesium Chlorate

Abstract

Acute administration of defoliant leads to structural, hemodynamic disorders and dystrophic changes in the cells of the cortex and medulla of the organ. The relative weight of the adrenal glands was significantly increased in comparison with the control. Expansion of the relative width of the adrenal cortex and its zones is noted. The volume of nuclei of cortical and chromaffin cells was significantly increased in comparison with the control. The vascular reaction manifests itself not only in hyperemia, but also in local hemorrhages. Determined by karyopyknosis in cortical cells, vacuolization of their cytoplasm. After a single injection of the pesticide, there is a decrease in the synthetic processes of the secretory cycle in the cells of the cortex zones. A decrease in the amount of lipids and ascorbic acid indicate an increase in the phase of hormone release from cortical cells. In the medulla, the content of N cells is increased, the secretory activity of most chromaffin cells is moderately expressed.