Evaluation of Anti-Diabetic Activity of Isolated Fractions of Allium Sativum

Abstract

The present study focuses the determination of the anti-diabetic activity of the extracted fractions of Allium sativum in rats with diabetes induced through STZ. The 20 mg/kg and 40 mg/kg doses of Allium sativum were given to the rats for 28 days. Using the accu-chek active test meter, blood glucose levels were measured to assess the anti-diabetic effects of the isolated fractions. Additionally, a comparison was made with the standard anti-diabetic medication, Pioglitazone, was given to another group of rats at a normal dose of 2.7 mg/kg. The results revealed that Allium sativum had significant anti-diabetic activity. Also, the Allium sativum remained safe till 300 mg/kg in acute toxic and 1000 mg/kg in sub-acute toxic studies and had photochemically. From these findings it can be inferred that Allium sativum has lowered FBG in experimentally induced diabetic rats.