Advancing Biomedical Frontiers: Unveiling The Potential Of 3d Bioprinting In Organ Regeneration

Main Article Content

Sayani Das
Sulogna Mitra
Monalisa Mallik
Soumili Banerjee
Subhajit Pal
Abhijit Kumar
Semanti Ghosh
Bidisha Ghosh
Subhasis Sarkar
Suranjana Sarkar

Abstract

The advent of 3D bioprinting marks a pivotal moment in biomedical research and healthcare, unlocking a realm of possibilities. This abstract explores the transformative potential of 3D bioprinting technology, its diverse applications in medical domains, and the inherent challenges it faces. 3D bioprinting represents a revolutionary fusion of three-dimensional printing precision with the intricacies of biological materials. This groundbreaking technology revolutionizes the fabrication of intricate, customized structures by layering bioinks containing living cells, biomaterials, and growth factors. These engineered constructs faithfully replicate the complex architecture of native tissues and organs, presenting unprecedented opportunities for progress in regenerative medicine, drug testing, and disease modeling. The versatility of 3D bioprinting extends across various medical fields. In regenerative medicine, the ability to craft tissue grafts and organ substitutes tailored to individual patients has the potential to transform transplantation procedures, overcoming challenges like donor shortages and organ rejection. Additionally, pharmaceutical companies are employing 3D bioprinting to generate functional tissue models for drug testing, reducing reliance on animal testing and speeding up drug development processes. 3D bioprinting represents a transformative technology with the potential to advance healthcare through personalized regenerative solutions, ethical drug testing practices, and an improved understanding of diseases.However, the adoption of 3D bioprinting is not without its challenges. The intricacy of the bioprinting process necessitates a profound understanding of cellular biology, materials science, and engineering. Overcoming hurdles related to ensuring cell viability and functionality within printed structures is paramount, along with the imperative to scale up production for clinical applications. Ethical and regulatory considerations also emerge, particularly in the context of printing human tissues and organs.

Downloads

Download data is not yet available.

Article Details

How to Cite
Sayani Das, Sulogna Mitra, Monalisa Mallik, Soumili Banerjee, Subhajit Pal, Abhijit Kumar, Semanti Ghosh, Bidisha Ghosh, Subhasis Sarkar, & Suranjana Sarkar. (2023). Advancing Biomedical Frontiers: Unveiling The Potential Of 3d Bioprinting In Organ Regeneration. Journal of Advanced Zoology, 44(S5), 2488–2493. https://doi.org/10.53555/jaz.v44iS5.3210
Section
Articles
Author Biographies

Sayani Das

Department of Microbiology, School of Life Sciences, Swami Vivekananda University, Barrackpore, West Bengal, India.

Sulogna Mitra

Department of Microbiology, School of Life Sciences, Swami Vivekananda University, Barrackpore, West Bengal, India.

Monalisa Mallik

Department of Microbiology, School of Life Sciences, Swami Vivekananda University, Barrackpore, West Bengal, India.

Soumili Banerjee

Department of Microbiology, School of Life Sciences, Swami Vivekananda University, Barrackpore, West Bengal, India.

Subhajit Pal

Department of Microbiology, School of Life Sciences, Swami Vivekananda University, Barrackpore, West Bengal, India.

Abhijit Kumar

Department of Microbiology, School of Life Sciences, Swami Vivekananda University, Barrackpore, West Bengal, India.

Semanti Ghosh

Department of Biotechnology, School of Life Sciences, Swami Vivekananda University, Barrackpore, West Bengal, India.

Bidisha Ghosh

Department of Biotechnology, School of Life Sciences, Swami Vivekananda University, Barrackpore, West Bengal, India.

Subhasis Sarkar

Department of Microbiology, School of Life Sciences, Swami Vivekananda University, Barrackpore, West Bengal, India.

Suranjana Sarkar

Department of Microbiology, School of Life Sciences, Swami Vivekananda University, Barrackpore, West Bengal, India.

References

Derakhshanfar, S., Mbeleck R., Xu K., Zhang X., Zhong W., Xing M. (2018). 3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances. Bioactive Materials, 3:144–156.

Di Bella, C., Duchi S., O’Connell C.D., Blanchard R., Augustine C., Yue Z., Thompson F., Richards C., Beirne S., Onofrillo C. (2018). In situ handheld three-dimensional bioprinting for cartilage regeneration . Journal of Tissue Engineering and Regenerative Medicine, 12:611–621.

Jovic, T. H., Combellack, E. J., Jessop, Z. M., & Whitaker, I. S. (2020). 3D Bioprinting and the Future of Surgery. Frontiers in surgery, 7, 609836.

Kačarević, Ž. P., Rider, P. M., Alkildani, S., Retnasingh, S., Smeets, R., Jung, O., Ivanišević, Z., & Barbeck, M. (2018). An Introduction to 3D Bioprinting: Possibilities, Challenges and Future Aspects. Materials (Basel, Switzerland), 11(11), 2199.

Lin H., Zhang D., Alexander P.G., Yang G., Tan J., Cheng A.W.M., Tuan R.S. (2013). Application of visible light-based projection stereolithography for live cell-scaffold fabrication with designed architecture. Biomaterials, 34:331–339.

Nishiyama, Y., Nakamura, M., Henmi, C., Yamaguchi, K., Mochizuki, S., Nakagawa, H., & Takiura, K. (2009). Development of a three-dimensional bioprinter: construction of cell supporting structures using hydrogel and state-of-the-art inkjet technology. Journal of biomechanical engineering, 131(3), 035001.

Norotte, C., Marga, F. S., Niklason, L. E., & Forgacs, G. (2009). Scaffold-free vascular tissue engineering using bioprinting. Biomaterials, 30(30), 5910–5917.

Panja, N., Maji, S., Choudhuri, S., Ali, K. A., & Hossain, C. M. (2022). 3D Bioprinting of Human Hollow Organs.The American Association of Pharmaceutical Scientists, 23(5), 139.

Papaioannou, T. G., Manolesou, D., Dimakakos, E., Tsoucalas, G., Vavuranakis, M., & Tousoulis, D. (2019). 3D Bioprinting Methods and Techniques: Applications on Artificial Blood Vessel Fabrication . Acta Cardiologica Sinica, 35(3), 284–289.

Qi, X., Pei P., Zhu M., Du X., Xin C., Zhao S., Li X., Zhu Y. (2017). Three dimensional printing of calcium sulfate and mesoporous bioactive glass scaffolds for improving bone regeneration in vitro and in vivo. Scientific Reports, 7:42556.

Rouwkema, J., Rivron, N. C., & van Blitterswijk, C. A. (2008). Vascularization in tissue engineering . Trends in biotechnology, 26(8), 434–441.

Saini, G., Segaran, N., Mayer, J. L., Saini, A., Albadawi, H., & Oklu, R. (2021). Applications of 3D Bioprinting in Tissue Engineering and Regenerative Medicine. Journal of clinical medicine, 10(21), 4966.

Tripathi, S., Mandal, S. S., Bauri, S., & Maiti, P. (2022). 3D bioprinting and its innovative approach for biomedical applications. MedComm, 4(1), e194.

Most read articles by the same author(s)

1 2 3 > >>