Revolutionizing the Biological Landscape: the Power of Genome Editing
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Abstract
In recent decades, the advent of genome editing has brought about profound transformations in biology, allowing for precise modifications to the genetic material of living organisms beyond traditional genetic manipulation methods. This summary explores the vast potential, diverse applications, and ethical considerations associated with genome editing. Led by CRISPR-Cas9, this technology revolutionizes genetic engineering by providing unparalleled accuracy and versatility. Scientists can now manipulate genes with unprecedented precision, impacting various fields such as agriculture and medicine. Genome editing facilitates the creation of genetically modified organisms with desirable traits, from enhancing crop disease resistance to pioneering human therapies. Moreover, it sheds light on gene function, offering crucial biological insights. Despite its transformative potential, ethical concerns accompany genome editing, especially in terms of editing the germ line and its implications for future generations. This necessitates ongoing discussions to address unintended consequences, highlighting the importance of responsible use. Ultimately, genome editing represents a revolutionary advancement with the potential to transform agriculture, medicine, and our understanding of life. Moving forward, inclusive dialogues involving scientists, ethicists, policymakers, and the public are essential to ensure the responsible application of genome editing for the benefit of humanity and the environment.
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References
Breier, D., & Peer, D. (2022). Genome editing in cancer: Challenges and potential opportunities . Bioactive materials, 21, 394–402.
Chandler, R. J., & Venditti, C. P. (2016). Gene Therapy for Metabolic Diseases. Translational science of rare diseases, 1(1), 73–89.
Chou, S. T., Leng, Q., & Mixson, A. J. (2012). Zinc Finger Nucleases: Tailor-made for Gene Therapy. Drugs of the future, 37(3), 183–196.
Gaj, T., Sirk, S. J., Shui, S. L., & Liu, J. (2016). Genome-Editing Technologies: Principles and Applications. Cold Spring Harbor perspectives in biology, 8(12), a023754.
German, D. M., Mitalipov, S., Mishra, A., & Kaul, S. (2019). Therapeutic Genome Editing in Cardiovascular Diseases. JACC. Basic to translational science, 4(1), 122–131.
Im, W., Moon, J., & Kim, M. (2016). Applications of CRISPR/Cas9 for Gene Editing in Hereditary Movement Disorders. Journal of movement disorders, 9(3), 136–143.
Kim, T. H., & Lee, S. W. (2022). Therapeutic Application of Genome Editing Technologies in Viral Diseases. International journal of molecular sciences, 23(10), 5399.
Li, Q., Qin, Z., Wang, Q., Xu, T., Yang, Y., & He, Z. (2019). Applications of Genome Editing Technology in Animal Disease Modeling and Gene Therapy. Computational and structural biotechnology journal, 17, 689–698.
Liu, W., Li, L., Jiang, J., Wu, M., & Lin, P. (2021). Applications and challenges of CRISPR-Cas gene-editing to disease treatment in clinics. Precision clinical medicine, 4(3), 179–191. https://doi.org/10.1093/pcmedi/pbab014
Ousterout, D. G., & Gersbach, C. A. (2016). The Development of TALE Nucleases for Biotechnology . Methods in molecular biology (Clifton, N.J.), 1338, 27–42.
Wu, S. S., Li, Q. C., Yin, C. Q., Xue, W., & Song, C. Q. (2020). Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases. Theranostics, 10(10), 4374–4382.
Xu, Y., & Li, Z. (2020). CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy. Computational and structural biotechnology journal, 18, 2401–2415.
Yamaguchi, T., Uchida, E., Okada, T., Ozawa, K., Onodera, M., Kume, A., Shimada, T., Takahashi, S., Tani, K., Nasu, Y., Mashimo, T., Mizuguchi, H., Mitani, K., & Maki, K. (2020). Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan. Human gene therapy, 31(19-20), 1043–1053.