Synthesis of (1-(2-((5-(4-Substitutedphenyl) Furan/Thiophen-2-Yl) Methylene) Hydrazineyl)-3-(4-Hydroxyphenyl)-1-Oxopropan-2-Yl)-4-(1H-Indol-3-Yl) Butanamide and It’s Pharmacological Studies

Abstract

A series of (1-(2-((5-(4-substitutedphenyl) furan/thiophen-2-yl) methylene) hydrazineyl)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-4-(1H-indol-3-yl) butanamide is synthesised and screened for antinflammatory activity by using Dexamethasone as a standard drug. Among the Screened derivatives bromine substituted and methyl substituted derivatives showed higher activity than other derivatives.