Synthesis of (1-(2-((5-(4-Substitutedphenyl) Furan/Thiophen-2-Yl) Methylene) Hydrazineyl)-3-(4-Hydroxyphenyl)-1-Oxopropan-2-Yl)-4-(1H-Indol-3-Yl) Butanamide and It’s Pharmacological Studies

Authors

  • Shilpa A.S Research scholar, Department of Chemistry, PET Research Foundation, PES college of Engineering Mandya, Karnataka, India
  • Satish Kumar.M Associate Professor, Department of Chemistry, PES college of Engineering Mandya, Karnataka, India

DOI:

https://doi.org/10.17762/jaz.v44iS-5.1573

Keywords:

Hydrazone, Heterocyclic compound, Indole-tyrosine.

Abstract

A series of (1-(2-((5-(4-substitutedphenyl) furan/thiophen-2-yl) methylene) hydrazineyl)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-4-(1H-indol-3-yl) butanamide is synthesised and screened for antinflammatory activity by using Dexamethasone as a standard drug. Among the Screened derivatives bromine substituted and methyl substituted derivatives showed higher activity than other derivatives.

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Published

2023-11-06

Issue

Vol. 44 No. S5 (2023)

Section

Articles

License

Copyright (c) 2023 Shilpa A.S, Satish Kumar.M

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.