A Study On Evaluations Of Doxofylline Tablets In Sr-Ds

Abstract

The main objective of present research investigation is to formulate the sustained release tablet of Doxofylline using 3 2 factorial design. Doxofylline, an anti-Asthmatic agent, belongs BCS class-III agent. The SR tablets of Doxofylline were prepared employing different concentrations of HPMC K100M and Chitosan in different combinations by Direct Compression technique using 3 2 factorial design. The concentration of Polymers, HPMC K100M and Chitosan required to achieve the desired drug release was selected as independent variables, X 1 and X 2 respectively whereas, time required for 10% of drug dissolution (t 10%), 50% (t 50%), 75% (t 75%) and 90% (t 90%) were selected as dependent variables. Totally nine formulations were designed, Formulated and are evaluated for hardness, friability, thickness, % drug content, In-vitro drug release. From the Results it was concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In- vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept, slope & regression coefficient were calculated. Polynomial equations were developed for t 10% , t 50% , t 75% , t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations (C 1 , C 2). According to SUPAC guidelines the formulation