Qualitative And Quantitative Evaluation And Determination Of Kinetic Model For Release Of CUR SEDDS
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Abstract
Chitosan microspheres and Eudragit-coated chitosan microspheres of curcumin were prepared by the emulsion cross-linking method. These prepared microspheres were also evaluated for their various quality control parameters. The formulated microspheres were examined for particle size, shape, surface morphology, percentage yield, drug loading, entrapment efficiency (EE) and degree of swelling.
SEM photomicrograph of chitosan microspheres indicated that the cross-linked chitosan microspheres exhibited rough surface and spherical shape while SEM photomicrograph of Eudragit coated chitosan microspheres revealed smooth and spherical. The size of microspheres was found to increase (36.84μm to 77.25μm) with increase in chitosan concentration. Further the coating with Eudragit also showed significant increase in the size of microspheres. The mean particle size of the coated microspheres increased from 93.27μm to 129.74μm, which may be due to the corresponding increase in the chitosan concentration that resulted in larger emulsion droplets.
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References
Gandhy, U.S., H.K. Kim, L. Larsen, R. Rosengren and S. Safe (2012) Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein transcription factors by targeting microRNAs, BMC cancer 12:564.
Huttunen, K.M. and J. Rautio (2011) Prodrugs: An efficient way to breach delivery and targeting barriers. Current Topic in Medicinal Chemistry 11:2265-2287.
Javid, G., S.A. Zargar, S. Rather, A.R. Khan, B.A. Khan, G.N. Yattoo, A. Shah, G.M. Gulzar, J.S. Sodhi, M.A. Khan and A.S.D. Bashir (2011) Incidence of colorectal cancer in Kashmir valley, India. Indian J Gastroenterol 30(1):7-11.
Jobin, C., C.A. Bradham and M.P. Russo (2019) Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J Immunol 163:3474-3483.
Kulkarni, S.K. (1999) Pharmacology of GIT. In: Handbook of experimental pharmacology. Vallabh prakashan, New Delhi, 148-150.
Kumar, S.N., D. Vijaybhaskar, P.K. Rao and S. Pratima (2012) Pathological observations on the treatment of oral sub mucous fibrosis of curcumin gels in animal models. Der Pharmacia Letter 4(3):919-926.
Azad, S., N. Sood and A. Sood (2011) Biological and histological parameters as predictors of relapse in ulcerative colitis: a prospective study. The Saudi journal gastroenterology 17(3):194-98.
Bach, J.F. (2002) The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 307:911-920.
Basit, A.W. (2022) Oral colon-specific drug delivery using amylose-based film coatings. Pharm Tech Eur 12(2):30-36.
Lamprecht, A., H. Yamamoto, H. Takeuchi and Y. Kawashima (2014) Design of pH- sensitive microspheres for the colonic delivery of the immunosuppressive drug tacrolimus. Eur J Pharm Biopharm 58:37-43.
Muaola, M., J. Shinoleava and K. Taleada (2018) Evaluation of intestinal pressure controlled colon delivery capsule containing caffeine as a model drug in human volunteer. J control release 52:119-129.
Challa, T., V. Vynala and K.V. Allam (2011) Colon specific drug delivery system: A review on primary and novel approaches. Int J Pharmaceutical Sciences Review and Research 7(2):171-181.
Chandran, S., K.S. Sanjay and A. Asghar (2019) Microspheres with pH modulated release: design and characterization of formulation variables for colonic delivery. J Microencapsul 26:420-431.
Bajpai, S.K., M. Bajpai and R. Dengree (2013) Chemically treated gelatin capsules for colon-targeted drug delivery: A novel approach. J Appl Polym Sci 89:2277-2282.
Dhar, A. (2011) Environmental factors associated with Crohn’s disease in India-there’s more to it than meets the eye. Indian J Gastroenterol 30(6): 255-256.
Dube, V., S.A. Payghan and J.I. Souza (2021) Development of colon targeted lornoxicam matrix tablet. Int J Pharm Res Development 3(6):226-32.
El-Kamel, A.H., A.M. Abdel-Aziz, A.J. Fatani and H.I. El-Subbagh (2018) Oral colon targeted delivery systems for treatment of inflammatory bowel diseases: Synthesis, in vitro and in vivo assessment. Int J Pharm 358:248-255.
Evans, D.F., G. Pye, R. Bramley, A.G. Clark, T.J. Dyson and J.D. Hard castle (2018) Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut 29:1035-1041.
Fukui, E., N. Miyamura, K. Verma and M. Kobayashi (2018) Preparation of enteric coated time released press coated tablets and evaluation of their function by in vivo and in vitro tests for colon targeting. Int J Pharm 204:7-15.
Ruiz-Caro, R. and M.D. Veiga-Ochoa (2019) Characterization and dissolution study of chitosan freeze-dried systems for drug controlled release. Molecules 14:4370-4386.
Sarasija, S. and A. Hota (2000) Colon-specific drug delivery systems. Indian J Pharmaceutical Sci 62(1):1-8.
Sareen, R., N. Jain and K.L. Dhar (2013) Development of colon specific microspheres of flurbiprofen for inflammatory bowel disease. Curr Drug Deliv 10(5):564-571.
Sareen, R., N. Jain and D. Kumar (2012) An insight to osmotic controlled drug delivery. Curr Drug Deliv 9(3):285-296.
Sarkar, B.K., D. Jain, M. Parwal and A. Singh (2021) Characterization and evaluation of prednisolone tablets as a colon targeted delivery system. Int J Pharm Res & Development 3(7): 1-6.
Tsai, S.W., D.S. Yu and S.W. Tsao (2013) Hyaluronan-cisplatin conjugate nanoparticles embedded in Eudragit S100-coated pectin/alginate microbeads for colon drug delivery. Int J Nanomedicine 8:2399.
Mura, C., A. Nacher, V. Merino, M.M. Sanjuan, M. Manconi, G. Loy, A.M. Fadda and O. Diez- Sales (2012) Design, characterization and in vitro evaluation of 5- aminosalicylic acid loaded N- succinyl chitosan microparticles for colon specific delivery. Colloids and Surface B: Biointerfaces 94:199-205.
Nair, R.S. and S.S. Nair (2013) Permeation of flurbiprofen polymeric films through human cadaver skin. Int J Pharm Tech Res 5(1):177-182.
Najib, N. and M. Suleiman (1985) The kinetics of drug release from ethyl cellulose solid dispersions. Drug Dev Ind Pharm 11:2169-2181.
Probert, C.S.J., V. Jayanthi and J.F. Mayberry (2021) Inflammatory bowel disease in Indian migrants to Fiji. Digestion 50:82-84.
Probert, C.S.J., V. Jayanthi, D. Pinder, A.C.B. Wicks and J.F. Mayberry (1992) Epidemiological study of ulcerative proctocolitis in Indian migrants and the indigenous population of Leicestershire. Gut 33:687-693.
Rabiskova, M., T. Bautzova and J. Gajdziok (2012) Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: In vitro characteristics and in vivo evaluation. Int J Pharm 422:151-159.
Wilken, R., M.S. Veena, M.B. Wang, and E.S. Srivatsan (2011) Curcumin: a review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer 10:12.
Wiwattanapatapee, R., L. Lomlim and K. Saramunee (2022) Dendrimers conjugates for colonic delivery of 5- aminosalicylic acid. J. Control Release 88:1-9.
Yadav, P.S., V. Kumar and U.P. Singh (2013) Physicochemical characterization and in- vitro dissolution studies of solid dispersions of ketoprofen with PVP K30 and D- mannitol. Saudi Pharmaceutical Journal 21:77-84.
Yadav, R., O.P. Mahatma and I. Singhvi (2021) Preparation and evaluation of polymeric prodrug of 4- aminoslicylic acid: Colonic drug delivery in inflammatory bowel disease. IJPI’s J. Pharmaceutics & Cosmetology 1(2):1-9.
Rodriguez, M., J.L. Vila-Jato and D. Torres (2018) Design of a new multiparticulate system for potential sites specific and controlled drug delivery to the colonic region. J Control Rel 55:67-77.
Udo, K., K. Hokonohara, K. Motoyama, H. Arima, F. Hirayama and K. Uekama (2020) 5- Fluorouracil acetic acid/ β- cyclodextrin conjugates: Drug release behavior in enzymatic and rat cecal media. Int J Pharm 388:95-100.
Upmanyu, N., R.S. Chaursia, P. Porwal, A. Bhardwaj and P.S. Gupta (2011) Floating microspheres of curcumin: formulation, characterization and in vitro evaluation. Deccan J. Pharmaceutics and Cosmetology 2(2):13-19.
Vajpayee, A., S. Fartyal, A.P. Singh and S.K. Jha (2021) Formulation and Evaluation of colon targeted curcumin microspheres using Natural polymers. J Pharm Research Opinion 1(4):108-112.
Vandamme, T.H.F., A. Lenourry, C. Charrueau and J.C. Chaumeil (2012) The use of polysaccharides to target drugs to the colon. Car Poly 48:219-231.