Development And Formulation Of Drug-Loaded Hydrogel For Skin Regenerative Potential
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Abstract
Skin injuries, whether due to trauma, burns, or chronic wounds, present a significant clinical challenge, highlighting the need for innovative regenerative therapies. This study focuses on the development and formulation of a drug-loaded hydrogel as a promising approach for skin regeneration. Hydrogel is designed to provide a supportive environment for cell proliferation, migration, and differentiation, while also delivering therapeutic agents to accelerate wound healing. Various biocompatible polymers and crosslinking methods are explored to optimize the hydrogel's mechanical properties, biodegradability, and drug release kinetics. Additionally, the study investigates the efficacy of different drugs, growth factors, and bioactive molecules in promoting angiogenesis, collagen synthesis, and tissue remodeling within the hydrogel scaffold. The developed drug-loaded hydrogel holds great potential for addressing a wide range of skin injuries and advancing the field of regenerative dermatology.
In summary, hydrogels represent a promising avenue in skin regenerative medicine due to their unique properties that support tissue repair, drug delivery, and wound healing processes. Ongoing research continues to explore innovative applications of hydrogels to address challenges in skin regeneration and wound treatment effectively.
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References
Arabpour Z, Abedi F, Salehi M, Baharnoori SM, Soleimani M, Djalilian AR. Hydrogel-Based Skin Regeneration. International Journal of Molecular Sciences. 2024 Feb 6;25(4):1982.
Tobin DJ. The anatomy and physiology of the skin. Springer Publishing Company, New York, New York, USA; 2011 Jun 13.
Slaughter BV, Khurshid SS, Fisher OZ, Khademhosseini A, Peppas NA. Hydrogels in regenerative medicine. Advanced materials. 2009 Sep 4;21(32‐33):3307-29.
Revete A, Aparicio A, Cisterna BA, Revete J, Luis L, Ibarra E, Segura González EA, Molino J, Reginensi D. Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications. International Journal of Biomaterials. 2022 Nov 7;2022.
Uppuluri VN, Sathanantham ST, Bhimavarapu SK, Elumalai L. Polymeric hydrogel scaffolds: skin tissue engineering and regeneration. Advanced Pharmaceutical Bulletin. 2022 May;12(3):437.
Zhu W, Zhang J, Wei Z, Zhang B, Weng X. Advances and progress in self-healing hydrogel and its application in regenerative medicine. Materials. 2023 Jan 31;16(3):1215.
Tottoli EM, Dorati R, Genta I, Chiesa E, Pisani S, Conti B. Skin wound healing process and new emerging technologies for skin wound care and regeneration. Pharmaceutics. 2020 Aug;12(8):735.
Cañedo-Dorantes L, Cañedo-Ayala M. Skin acute wound healing: a comprehensive review. International journal of inflammation. 2019 Jun 2;2019.
Sorg H, Tilkorn DJ, Hager S, Hauser J, Mirastschijski U. Skin wound healing: an update on the current knowledge and concepts. European Surgical Research. 2017 Dec 15.
Almadani YH, Vorstenbosch J, Davison PG, Murphy AM. Wound healing: A comprehensive review. InSeminars in plastic surgery 2021 Jul 15.
Liang Y, He J, Guo B. Functional hydrogels as wound dressing to enhance wound healing. ACS nano. 2021 Aug 10;15(8):12687-722.
Firlar I, Altunbek M, McCarthy C, Ramalingam M, Camci-Unal G. Functional hydrogels for treatment of chronic wounds. Gels. 2022 Feb 17;8(2):127.
Hao R, Cui Z, Zhang X, Tian M, Zhang L, Rao F, Xue J. Rational design and preparation of functional hydrogels for skin wound healing. Frontiers in Chemistry. 2022 Jan 24;9:839055.
Qi L, Zhang C, Wang B, Yin J, Yan S. Progress in hydrogels for skin wound repair. Macromolecular Bioscience. 2022 Jul;22(7):2100475.
He Y, Cen Y, Tian M. Immunomodulatory hydrogels for skin wound healing: cellular targets and design strategy. Journal of Materials Chemistry B. 2024.
Mao H, Zhao S, He Y, Feng M, Wu L, He Y, Gu Z. Multifunctional polysaccharide hydrogels for skin wound healing prepared by photoinitiator-free crosslinking. Carbohydrate Polymers. 2022 Jun 1;285:119254.
Das R, Samanta HS, Bhattacharjee C. Hydrogel: Polymeric smart material in drug delivery. InMaterials Science Forum 2016 Nov 20 (Vol. 875, pp. 45-62). Trans Tech Publications Ltd.
Jeong KH, Park D, Lee YC. Polymer-based hydrogel scaffolds for skin tissue engineering applications: a mini-review. Journal of Polymer Research. 2017 Jul;24:1-0.
Kamoun EA, Kenawy ER, Chen X. A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings. Journal of advanced research. 2017 May 1;8(3):217-33.
Zhang H, Lin X, Cao X, Wang Y, Wang J, Zhao Y. Developing natural polymers for skin wound healing. Bioactive Materials. 2024 Mar 1;33:355-76.
Pandurangan S, Murugesan P, Ramudu KN, Krishnaswamy B, Ayyadurai N. Enhanced cellular uptake and sustained transdermal delivery of collagen for skin regeneration. ACS Applied Bio Materials. 2020 Oct 26;3(11):7540-9.
Xu L, Zhang Z, Jorgensen AM, Yang Y, Jin Q, Zhang G, Cao G, Fu Y, Zhao W, Ju J, Hou R. Bioprinting a skin patch with dual-crosslinked gelatin (GelMA) and silk fibroin (SilMA): An approach to accelerating cutaneous wound healing. Materials Today Bio. 2023 Feb 1;18:100550.
Naomi R, Bahari H, Ridzuan PM, Othman F. Natural-based biomaterial for skin wound healing (Gelatin vs. Collagen): expert review. Polymers 13: 2319.
Ndlovu SP, Ngece K, Alven S, Aderibigbe BA. Gelatin-based hybrid scaffolds: promising wound dressings. Polymers. 2021 Aug 31;13(17):2959.
Li J, Guan S, Su J, Liang J, Cui L, Zhang K. The development of hyaluronic acids used for skin tissue regeneration. Current Drug Delivery. 2021 Aug 1;18(7):836-46.
Anderegg U, Simon JC, Averbeck M. More than just a filler–the role of hyaluronan for skin homeostasis. Experimental dermatology. 2014 May;23(5):295-303.
Xia Y, Wang D, Liu D, Su J, Jin Y, Wang D, Han B, Jiang Z, Liu B. Applications of chitosan and its derivatives in skin and soft tissue diseases. Frontiers in Bioengineering and Biotechnology. 2022 May 2;10:894667.
Sánchez-Machado DI, López-Cervantes J, Martínez-Ibarra DM, Escárcega-Galaz AA, Vega-Cázarez CA. The use of chitosan as a skin-regeneration agent in burns injuries: A review. e-Polymers. 2022 Jan 4;22(1):75-86.
Amor IB, Emran TB, Hemmami H, Zeghoud S, Laouini SE. Nanomaterials based on chitosan for skin regeneration: an update. International Journal of Surgery. 2023 Mar 1;109(3):594-6.
Boucard N, Viton C, Agay D, Mari E, Roger T, Chancerelle Y, Domard A. The use of physical hydrogels of chitosan for skin regeneration following third-degree burns. Biomaterials. 2007 Aug 1;28(24):3478-88.
Nqoro X, Alven S, Buyana B, Feketshane Z, Aderibigbe BA. Alginate-based wound dressings for skin healing and regeneration. InNatural Polymers in Wound Healing and Repair 2022 Jan 1 (pp. 381-416). Elsevier.
Froelich A, Jakubowska E, Wojtyłko M, Jadach B, Gackowski M, Gadziński P, Napierała O, Ravliv Y, Osmałek T. Alginate-based materials loaded with nanoparticles in wound healing. Pharmaceutics. 2023 Apr 4;15(4):1142.
Aderibigbe BA, Buyana B. Alginate in wound dressings. Pharmaceutics. 2018 Apr 2;10(2):42.
Soliman M, Sadek AA, Abdelhamid HN, Hussein K. Graphene oxide-cellulose nanocomposite accelerates skin wound healing. Research in Veterinary Science. 2021 Jul 1;137:262-73.
Hickey RJ, Pelling AE. Cellulose biomaterials for tissue engineering. Frontiers in bioengineering and biotechnology. 2019 Mar 22;7:45.
Tudoroiu EE, Dinu-Pîrvu CE, Albu Kaya MG, Popa L, Anuța V, Prisada RM, Ghica MV. An overview of cellulose derivatives-based dressings for wound-healing management. Pharmaceuticals. 2021 Nov 24;14(12):1215.
Kohli N, Sharma V, Brown SJ, García-Gareta E. Synthetic polymers for skin biomaterials. InBiomaterials for skin repair and regeneration 2019 Jan 1 (pp. 125-149). Woodhead Publishing.
Elango J, Zamora-Ledezma C, Maté-Sánchez de Val JE. Natural vs Synthetic Polymers: How Do They Communicate with Cells for Skin Regeneration—A Review. Journal of Composites Science. 2023 Sep 13;7(9):385.
Guo B, Ma PX. Synthetic biodegradable functional polymers for tissue engineering: a brief review. Science China Chemistry. 2014 Apr;57:490-500.
Kumar A, Han SS. PVA-based hydrogels for tissue engineering: A review. International journal of polymeric materials and polymeric biomaterials. 2017 Mar 4;66(4):159-82.
Zulkiflee I, Fauzi MB. Gelatin-polyvinyl alcohol film for tissue engineering: A concise review. Biomedicines. 2021 Aug 9;9(8):979.
Zhang J, Yang S, Yang X, Xi Z, Zhao L, Cen L, Lu E, Yang Y. Novel fabricating process for porous polyglycolic acid scaffolds by melt-foaming using supercritical carbon dioxide. ACS Biomaterials Science & Engineering. 2018 Feb 12;4(2):694-706.
Oh S, Seo SB, Kim G, Batsukh S, Park CH, Son KH, Byun K. Poly-D, L-lactic acid filler increases extracellular matrix by modulating macrophages and adipose-derived stem cells in aged animal skin. Antioxidants. 2023 Jun 1;12(6):1204.
Zuber A, Borowczyk J, Zimolag E, Krok M, Madeja Z, Pamula E, Drukala J. Poly (L-lactide-co-glycolide) thin films can act as autologous cell carriers for skin tissue engineering. Cellular and Molecular Biology Letters. 2014 Jun 1;19(2):297-314.
Wang X, Li Q, Hu X, Ma L, You C, Zheng Y, Sun H, Han C, Gao C. Fabrication and characterization of poly (l-lactide-co-glycolide) knitted mesh-reinforced collagen–chitosan hybrid scaffolds for dermal tissue engineering. Journal of the mechanical behavior of biomedical materials. 2012 Apr 1;8:204-15.
Homaeigohar S, Boccaccini AR. Nature-derived and synthetic additives to poly (ɛ-caprolactone) nanofibrous systems for biomedicine; an updated overview. Frontiers in Chemistry. 2022 Jan 19;9:809676.
Ghorbanzadeh Sheish S, Emadi R, Ahmadian M, Sadeghzade S, Tavangarian F. Fabrication and characterization of polyvinylpyrrolidone-eggshell membrane-reduced graphene oxide nanofibers for tissue engineering applications. Polymers. 2021 Mar 16;13(6):913.
Keirouz A, Fortunato G, Zhang M, Callanan A, Radacsi N. Nozzle-free electrospinning of Polyvinylpyrrolidone/Poly (glycerol sebacate) fibrous scaffolds for skin tissue engineering applications. Medical engineering & physics. 2019 Sep 1;71:56-67.
Singh PN, Byram PK, Das L, Chakravorty N. Natural Polymer-Based Thin Film Strategies for Skin Regeneration in Lieu of Regenerative Dentistry. Tissue Engineering Part C: Methods. 2023 Jun 1;29(6):242-56.
Das P, Manna S, Roy S, Nandi SK, Basak P. Polymeric biomaterials-based tissue engineering for wound healing: a systemic review. Burns & Trauma. 2023;11:tkac058.
Talikowska M, Fu X, Lisak G. Application of conducting polymers to wound care and skin tissue engineering: A review. Biosensors and Bioelectronics. 2019 Jun 15;135:50-63.
Mbese Z, Alven S, Aderibigbe BA. Collagen-based nanofibers for skin regeneration and wound dressing applications. Polymers. 2021 Dec 13;13(24):4368.
Sharma P, Kumar P, Sharma R, Bhatt VD, Dhot PS. Tissue engineering; current status & futuristic scope. Journal of medicine and life. 2019 Jul;12(3):225.
Lynch CR, Kondiah PP, Choonara YE. Advanced strategies for tissue engineering in regenerative medicine: A biofabrication and biopolymer perspective. Molecules. 2021 Apr 26;26(9):2518.
Bhardwaj N, Chouhan D, Mandal BB. 3D functional scaffolds for skin tissue engineering. InFunctional 3D tissue engineering scaffolds 2018 Jan 1 (pp. 345-365). Woodhead Publishing.
Cai R, Gimenez-Camino N, Xiao M, Bi S, DiVito KA. Technological advances in three-dimensional skin tissue engineering. Reviews on Advanced Materials Science. 2023 Feb 2;62(1):20220289.
Chaudhari AA, Vig K, Baganizi DR, Sahu R, Dixit S, Dennis V, Singh SR, Pillai SR. Future prospects for scaffolding methods and biomaterials in skin tissue engineering: a review. International journal of molecular sciences. 2016 Nov 25;17(12):1974.
Yang Y, Li B, Wang M, Pan S, Wang Y, Gu J. Effect of natural polymer materials on skin healing based on internal wound microenvironment: a review. Frontiers in Chemistry. 2023;11.