Agmatine Attenuates Oxidative Stress In Alcohol-Related Neurodevelopmental Disorder In Prenatal Ethanol Exposure Rat Model
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Abstract
The present study investigates the potential of agmatine, a neuromodulator with antioxidant properties, as a therapeutic intervention for addressing behavioural abnormalities in offspring with prenatal ethanol exposure. Though underlying pathology remains to be investigated, existing literature examined involvement oxidative stress resulted through several pathways in prenatal ethanol exposure. In the present study female SD rats were administered intragastrically with 0 or 6 g/kg ethanol (20 % wt/vol) from gestation days 9 to 20 to induce ADHD-like behavioural deficits in offspring. After weaning, male offspring were assigned to treatment groups and received agmatine intraperitoneally from postnatal day 21 to 35. The results showed that prenatally ethanol exposed offspring possessed hyperactivity, anxiety and depression like behaviour. Treatment with agmatine (40 and 80 mg/kg) and its modulators L-arginine (60 mg/kg), Arcaine (30 mg/kg) and Aminoguanidine (50 mg/kg) effectively reduced the hyperactivity in adult offspring and also shows anxiolytic and antidepressant action in EPM and FST. Additionally, prenatal ethanol exposure resulted in impaired attention which was reverse by chronic treatment agmatine and modulators. Also, offspring showed cognitive impaired with agmatine suggests that agmatine may play a crucial role in mitigating the neurodevelopmental consequences of prenatal alcohol exposure. Overall, our findings highlight the promising potential of agmatine as a novel pharmacological approach for addressing attention deficits associated with prenatal ethanol exposure and underscore the need for further research in this area.
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