Formulation And Evaluation Of Transdermal Herbal Gel Formulation Containing Ethanolic Extract Of Zingiber Officinale

Abstract

Because of widespread cultural approval. Strong acceptance by human body, and reduced occurrence of side effects, about 75-80% of the worldwide population, especially in less developed areas, continues to favor herbal remedies as their main option for fundamental healthcare. Herbal treatments comprise botanical or plant-based components and serve to address injuries, infections, and ailments. They are also employed for preventive health measures and to facilitate the recovery process. This research explored the possible therapeutic advantages of Zingiber officinale, commonly recognized as ginger, a naturally occurring anti-inflammatory substance with extensive culinary use. Numerous investigations have highlighted the advantages of ginger in managing conditions such as morning sickness, chronic dyspepsia, hypoglycemia, risk factors for heart disease, chemotherapy-induced nausea, and menstrual discomfort. Ginger ethanolic extract preparations in the form of transdermal gel consist of different concentrations and combinations of Carbopol 934 and Carbopol 940. All gel formulations exhibited favorable characteristics such as Spreadability, uniformity, Viscosity, and extrusion. Among these compositions, formulation F3, which contains Carbopol 934, displayed the highest release of the active ingredient in vitro and the ethanolic extract demonstrated significant anti-inflammatory effects in vitro.