Green synthesis of Platinum nanoparticles from Moringa oleifera Lam. and its antimicrobial efficacy.
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Abstract
Integration of nanoscience in medicine leads to the development of biomedical products that helps the society in a faster and safer manner.In the present studies platinum nanoparticles were synthesized by green synthesis route using aqueous extracts of Moringa oleifera and characterization was done through UV, SEM, TEM, FT-IR and XRD.The synthesized nanoparticle were spherical in shape with an average size of 20 nm. Various bioactive compounds present in aqueous extract of this plant were responsible for bio reduction of nanoparticles. In antimicrobial activity, It was observed that against E. coli maximum zone was at 80µg/ml ( IZ-18mm). Against B. subtilis no activity was observed at initial concentration, however nanoparticles showed zone at 60 and 80µg/ml respectively (IZ-10 and 12 mm). Further against P. aeruginosa nanoparticles showed activity at all dilutions. S. aureus was found to be resistant as no activity was observed except at 60µg/ml. Further when we tested these nanoparticles against different fungal strains it was observed that against F. oxysporium sample showed activity at all concentration, however maximum zone was observed at 60µg/ml (IZ-14mm). Against P. funicolusum it was observed that activity was low as compared to other strains. It was observed that C. albicans was found to be resistant at all concentrations except 80µg/ml where some activity was observed (IZ- 12mm. Further it was observed that against T. reesei nanoparticles had best activity at all concentrations. Maximum activity was observed at 80µg/ml (IZ- 18mm) .Result showed the biosynthesis of platinum nanoparticles using aqueous extract of Moringa oleifera is a clean, inexpensive and safe method that is free from toxic substance and consequently does not have any side effects.
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