Evaluation Of The Micronutrient Profile In The Serum Of Diabetes Mellitus Type II Patients And Healthy Individuals With Periodontitis
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Abstract
Background: Diabetes Mellitus Type II (DM-II) and periodontitis are interlinked chronic conditions with complex pathophysiological mechanisms. Micronutrient deficiencies have been implicated in both conditions, but the evaluation of their serum profile in individuals with DM-II and periodontitis remains underexplored. Understanding the micronutrient status in these populations could provide valuable insights into their nutritional needs and potential therapeutic interventions.
Materials and Methods: Serum samples were collected from DM-II patients with periodontitis (n=50), healthy individuals with periodontitis (n=50), and healthy controls without periodontitis (n=50). Micronutrient analysis was performed using high-performance liquid chromatography (HPLC) to quantify levels of vitamins (e.g., A, C, D, E), minerals (e.g., zinc, iron, magnesium), and antioxidants (e.g., selenium, glutathione). Statistical analysis was conducted using ANOVA and post-hoc tests to compare micronutrient levels among the groups.
Results: In DM-II patients with periodontitis, serum levels of vitamin C were significantly lower (p < 0.05) compared to both healthy individuals with periodontitis and healthy controls without periodontitis. Similarly, levels of vitamin D and zinc were significantly decreased (p < 0.05) in DM-II patients with periodontitis compared to healthy controls without periodontitis. However, no significant differences were observed in the levels of other micronutrients among the groups.
Conclusion: This study highlights distinct alterations in the serum micronutrient profile of DM-II patients with periodontitis, particularly lower levels of vitamin C, D, and zinc. These findings suggest the importance of nutritional interventions targeting these deficiencies in managing the comorbidity of DM-II and periodontitis. Further research is warranted to elucidate the mechanistic links between micronutrient status and the pathogenesis of these chronic conditions.
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References
Löe H, Brown LJ. "Early onset periodontitis in the United States of America." Journal of Periodontology. 1991; 62(10): 608-16.
Mealey BL, Oates TW. "Diabetes mellitus and periodontal diseases." Journal of Periodontology. 2006; 77(8): 1289-303.
American Diabetes Association. "Diagnosis and classification of diabetes mellitus." Diabetes Care. 2014; 37(Suppl 1): S81-S90.
Tonetti MS, Greenwell H, Kornman KS. "Staging and grading of periodontitis: Framework and proposal of a new classification and case definition." Journal of Periodontology. 2018; 89(Suppl 1): S159-S172.
Löe H. "Periodontal disease: The sixth complication of diabetes mellitus." Diabetes Care. 1993; 16(1): 329-34.
Taylor GW, Borgnakke WS. "Periodontal disease: associations with diabetes, glycemic control and complications." Oral Diseases. 2008; 14(3): 191-203.
Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, et al. "Periodontitis and diabetes: a two-way relationship." Diabetologia. 2012; 55(1): 21-31.
Chapple IL, Genco R. "Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases." Journal of Periodontology. 2013; 84(4 Suppl): S106-S112.
Graves DT, Kayal RA. "Diabetes-induced impairment of angiogenesis in periodontal disease: a mini-review." Journal of Dental Research. 2006; 85(10): 1024-9.
Engebretson S, Chertog R, Nichols A, Hey-Hadavi J, Celenti R, Grbic J. "Plasma levels of tumour necrosis factor-alpha in patients with chronic periodontitis and type 2 diabetes." Journal of Clinical Periodontology. 2007; 34(1): 18-24.
Ebersole JL, Machen RL, Steffen MJ, Willmann DE. "Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis." Clinical Experimental Immunology. 1997; 107(2): 347-52.
Chapple IL, Matthews JB. "The role of reactive oxygen and antioxidant species in periodontal tissue destruction." Periodontology 2000. 2007; 43(1): 160-232.
Wintergerst ES, Maggini S, Hornig DH. "Contribution of selected vitamins and trace elements to immune function." Annals of Nutrition and Metabolism. 2007; 51(4): 301-23.
Tapsell LC, Hemphill I, Cobiac L, Patch CS, Sullivan DR, Fenech M, et al. "Health benefits of herbs and spices: the past, the present, the future." Medical Journal of Australia. 2006; 185(S4): S4-S24.