Comparative Study Of Analgesia Of Ketorolac, Tramadol, And Flupirtine In The Treatment Of Third Molar Surgery
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Abstract
Background: Third molar surgery is a common dental procedure often associated with significant postoperative pain. This study aimed to compare the efficacy of three commonly used analgesic agents, ketorolac, tramadol, and flupirtine, in managing postoperative pain following third molar surgery.
Materials and Methods: A randomized controlled trial was conducted with 150 patients who underwent third molar extraction. The patients were divided into three groups, with 50 patients in each group. Group A received ketorolac 10 mg orally every 6 hours, Group B received tramadol 50 mg orally every 6 hours, and Group C received flupirtine 100 mg orally every 8 hours for 72 hours post-surgery. Pain intensity was assessed using a visual analog scale (VAS), and the total analgesic consumption was recorded. Adverse effects were monitored throughout the study period.
Results: The mean pain scores at different time intervals (0-24 hours, 24-48 hours, and 48-72 hours) were significantly lower in the ketorolac group compared to the tramadol and flupirtine groups (p < 0.05). The total analgesic consumption in the ketorolac group was significantly lower (p < 0.05) than in the tramadol and flupirtine groups. Adverse effects were mild and comparable among the three groups.
Conclusion: Ketorolac demonstrated superior analgesic efficacy in the management of postoperative pain following third molar surgery when compared to tramadol and flupirtine. It also resulted in reduced analgesic consumption and had a similar safety profile. Therefore, ketorolac may be considered the preferred analgesic agent for patients undergoing third molar surgery.
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