Evaluating 2-[(E)-2-Substituted-Ethenyl]-1,3-Benzoxazoles Against Photosynthesis Inhibition Activity
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Abstract
The total twelve compounds 2-[(E)-2-substituted-ethenyl]-1,3-benzoxazoles[1-12] were tested for the capacity to block photosynthetic electrons transport (PET) in chloroplasts of spinach. 2, 8, and 4 had the strongest activity against M. TB, M. kansasii, and M. avium, and it was much more effective against M. avium than isoniazid. The most potential ortho-substituted molecule, 2-[(E)-2-(2-methoxyphenyl)ethenyl], inhibited PET. It took 76.3 mol/L of -1,3-benzoxazole to block PET, but much less of the para-substituted compounds were able to do this. The inhibitory location of the investigated chemicals is on the donor side of photosystem II. The links between structure and their activity are examined.
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