Multisystem Inflammatory Syndrome In Children (Mis-C) Post Covid Infection In Central India: A Prospective Observational Study

Main Article Content

Dr. Rizwan Ahmed
Dr. Swapnali Bansode

Abstract

Aim Of Study: To evaluate clinical presentations and outcomes of patients with MIS-C in children


Method:  It is a prospective observational study that will be conducted in the Department of Paediatrics, NKPSIMS Medical College, Nagpur. All children admitted with MIS-C at our Hospital, aged 1 month to 18 years, from March 2021 to October 2023 were recruited into the study.


Results: There were 20 children presented with MIS-C post covid infection. Age and gender-wise associations along with common symptoms seen with post-covid infection were studied. The majority of cases were mild to moderate cases which were treated according to the category of illness. There was one mortality in category 4.


Conclusion: In this study, we will highlight the clinical spectrum and outcome of MIS-C secondary to covid19 infection in children and summarise the available evidence to provide insights into current clinical practice and implications for future research directions

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How to Cite
Dr. Rizwan Ahmed, & Dr. Swapnali Bansode. (2024). Multisystem Inflammatory Syndrome In Children (Mis-C) Post Covid Infection In Central India: A Prospective Observational Study. Journal of Advanced Zoology, 45(1), 966–971. https://doi.org/10.53555/jaz.v45i1.3517
Section
Articles
Author Biographies

Dr. Rizwan Ahmed

Assistant Professor, Department of Pediatrics, NKP Salve Institute of Medical Sciences & Research Centre, and Lata Mangeshkar Hospital, Nagpur.

Dr. Swapnali Bansode

Associate Professor, Department of Pediatrics NKPSIMS, Nagpur

References

WHO issues guidelines on the treatment of children with multisystem inflammatory syndrome associated with COVID-19: World Health Organisation: 23 November 2021 . Available from: https://www.who.int/news/item/23-11-2021-who-issues-guidelines-on-the-treatment-of-children-with-multisystem-inflammatory-syndrome-associated-with-covid-19 assessed on 13-3-2022

Belhadjer Z, Meot M, Bajolle F, et al. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemicexternal icon. Circulation 2020.

Liu W, Zhang Q, Chen J, Xiang R, Song H, Shu S, Chen L, Liang L, Zhou J, You L, et al.. Detection of COVID-19 in children in early January 2020 in Wuhan, China.N Engl J Med. 2020; 382:1370–1371.

Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, Guo Q, Sun X, Zhao D, Shen J, et al.. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding.Nat Med. 2020; 26:502–505. doi: 10.1038/s41591-020-0817-4

Godfred-Cato S, Bryant B, Leung J, et al. COVID-19–Associated Multisystem Inflammatory Syndrome in Children — United States, March–July 2020. MMWR Morb Mortal Wkly Rep 2020;69:1074–1080. DOI: http://dx.doi.org/10.15585/mmwr.mm6932e2external icon.

Jain S, Sen S, Lakshmivenkateshiah S, Bobhate P, Venkatesh S, Udani S, Shobhavat L, Andankar P, Karande T, Kulkarni S. Multisystem Inflammatory Syndrome in Children With COVID-19 in Mumbai, India. Indian Pediatr. 2020 Nov 15;57(11):1015-1019. doi: 10.1007/s13312-020-2026-0. Epub 2020 Aug 11. PMID: 32788432; PMCID: PMC7678602.

Whittaker E, Bamford A, Kenny J, Kaforou M, Jones CE, Shah P, Ramnarayan P, Fraisse A, Miller O, Davies P, Kucera F, Brierley J, McDougall M, Carter M, Tremoulet A, Shimizu C, Herberg J, Burns JC, Lyall H, Levin M; PIMS-TS Study Group and EUCLIDS and PERFORM Consortia. Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. JAMA. 2020 Jul 21;324(3):259-269. doi: 10.1001/jama.2020.10369. PMID: 32511692; PMCID: PMC7281356.

Balasubramanian S, Nagendran TM, Ramachandran B, Ramanan AV. Hyper-inflammatory Syndrome in a Child With COVID-19 Treated Successfully With Intravenous Immunoglobulin and Tocilizumab. Indian Pediatr. 2020 Jul 15;57(7):681-683. doi: 10.1007/s13312-020-1901-z. Epub 2020 May 10. PMID: 32393681; PMCID: PMC7387261.

Bhat CS, Gupta L, Balasubramanian S, Singh S, Ramanan AV. Hyperinflammatory Syndrome in Children Associated With COVID-19: Need for Awareness. Indian Pediatr. 2020 Oct 15;57(10):929-935. doi: 10.1007/s13312-020-1997-1. Epub 2020 Jul 15. PMID: 32683336; PMCID: PMC7605487.

Acharyya BC, Acharyya S, Das D. Novel Coronavirus Mimicking Kawasaki Disease in an Infant. Indian Pediatr. 2020 Aug 15;57(8):753-754. doi: 10.1007/s13312-020-1924-5. Epub 2020 May 22. PMID: 32441271; PMCID: PMC7444159.

Dhanalakshmi K, Venkataraman A, Balasubramanian S, Madhusudan M, Amperayani S, Putilibai S, Sadasivam K, Ramachandran B, Ramanan AV. Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children. Indian Pediatr. 2020 Nov 15;57(11):1010-1014. doi: 10.1007/s13312-020-2025-1. Epub 2020 Aug 6. PMID: 32769230; PMCID: PMC7678572.

Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, Zhang W, Wang Y, Bao S, Li Y, Wu C, Liu H, Liu D, Shao J, Peng X, Yang Y, Liu Z, Xiang Y, Zhang F, Silva RM, Pinkerton KE, Shen K, Xiao H, Xu S, Wong GWK; Chinese Pediatric Novel Coronavirus Study Team. SARS-CoV-2 Infection in Children. N Engl J Med. 2020 Apr 23;382(17):1663-1665. doi: 10.1056/NEJMc2005073. Epub 2020 Mar 18. PMID: 32187458; PMCID: PMC7121177.

Castagnoli R, Votto M, Licari A, et al. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review. JAMA Pediatr. 2020;174(9):882–889. doi:10.1001/jamapediatrics.2020.1467

Parri N, Lenge M, Buonsenso D; Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) Research Group. Children with Covid-19 in Pediatric Emergency Departments in Italy. N Engl J Med. 2020 Jul 9;383(2):187-190. doi: 10.1056/NEJMc2007617. Epub 2020 May 1. PMID: 32356945; PMCID: PMC7206930.

Riphagen S, Gomez X, Gonzalez-Martinez C, et al. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 2020;395:1607–8.

Verdoni L, Mazza A, Gervasoni A, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet 2020. doi:10.1016/S0140-6736(20)31103-X