A Comprehensive Review: COVID-19 And Post-Covid Versus Thromboembolism
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Abstract
In spite of the fact that COVID-19 was previously predominantly believed to be a respiratory ailment, rapidly increasing data point to a significant prevalence of venous thromboembolic consequences in the disease. This review article's main goal was to determine if there was a requirement to raise knowledge of PE (Pulmonary Embolism) in the aftermath of the COVID-19 outbreak given the still-weak epidemiologic data. The gathered studies were subjected to a critical evaluation and literature search. A digital search of Science Direct, Google Scholar, PubMed, and Scopus until June 2022. COVID-19’s lasting effects on health are yet mostly unknown. The pathophysiology of pulmonary embolism is highlighted in this review, along with the significance of being aware of the possible ways that enhanced the risk of VTE (Venous Thromboembolism) in patients suffering from post- COVID-19, including those who have a moderate or asymptomatic illness. To define suitable clinical care recommendations for the avoidance of thromboembolic consequences in the critically sick and post-COVID-19 phase, further study is necessary.
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References
Pneumonia of unknown cause — China: disease outbreak news. Geneva: World Health Organization, January 5, 2020 (https:// www.who.int/csr/don/05-january-2020-pneumonia-of-unkow n-cause- china/en/. opens in new tab)
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., ...& Cao, B. (2020).Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The lancet, 395(10229), 1054-1062.
Poissy, J., Goutay, J., Caplan, M., Parmentier, E., Duburcq, T., Lassalle, F., ...& Susen, S. (2020). Pulmonary embolism in patients with COVID- 19: awareness of an increased prevalence. Circulation, 142(2), 184-186.
Grillet, F., Behr, J., Calame, P., Aubry, S., &Delabrousse, E. (2020). Acute pulmonary embolism associated with COVID-19 pneumonia detected with pulmonary CT angiography. Radiology, 296(3), E186- E188.
Léonard-Lorant, I., Delabranche, X., Séverac, F., Helms, J., Pauzet, C., Collange, O., ...& Ohana, M. (2020). Acute pulmonary embolism in patients with COVID-19 at CT angiography and relationship to d-dimer levels. Radiology, 296(3), E189-E191.
Llitjos, J. F., Leclerc, M., Chochois, C., Monsallier, J. M., Ramakers, M., Auvray, M., & Merouani, K. (2020). High incidence of venous thromboembolic events in anticoagulated severe COVID‐19 patients. Journal of Thrombosis and Haemostasis, 18(7), 1743-1746.
Zuckier, L. S., Moadel, R. M., Haramati, L. B., & Freeman, L. M. (2020). Diagnostic evaluation of pulmonary embolism during the COVID-19 pandemic. Journal of Nuclear Medicine, 61(5), 630-631.
Danzi GB, Lof M, Galeazzi G, Gherbesi E (2020) Acute pulmonary embolism and COVID-19 pneumonia: a random association? Eur Heart J 41:1858
Tang, N., Bai, H., Chen, X., Gong, J., Li, D., & Sun, Z. (2020). Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. Journal of thrombosis and haemostasis, 18(5), 1094-1099.
Nadkarni, G. N., Lala, A., Bagiella, E., Chang, H. L., Moreno, P. R., Pujadas, E., ... & Fuster, V. (2020). Anticoagulation, bleeding, mortality, and pathology in hospitalized patients with COVID-19. Journal of the American College of Cardiology, 76(16), 1815-1826.
Thachil, J., Tang, N., Gando, S., Falanga, A., Cattaneo, M., Levi, M., ...& Iba, T. (2020). ISTH interim guidance on recognition and management of coagulopathy in COVID‐19. Journal of Thrombosis and Haemostasis, 18(5), 1023-1026.
Bikdeli, B., Madhavan, M. V., Jimenez, D., Chuich, T., Dreyfus, I., Driggin, E., ...& Lip, G. Y. (2020). COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC state-of-the-art review. Journal of the American college of cardiology, 75(23), 2950-2973.
Kollias, A., Kyriakoulis, K. G., Lagou, S., Kontopantelis, E., Stergiou, G. S., & Syrigos, K. (2021). Venous thromboembolism in COVID-19: A systematic review and meta-analysis. Vascular medicine, 26(4), 415-425.
Oudkerk, M., Büller, H. R., Kuijpers, D., van Es, N., Oudkerk, S. F., McLoud, T., ... & van Beek, E. J. (2020). Diagnosis, prevention, and treatment of thromboembolic complications in COVID-19: report of the National Institute for Public Health of the Netherlands. Radiology, 297(1), E216-E222.
Gerotziafas, G. T., Catalano, M., Colgan, M. P., Pecsvarady, Z., Wautrecht, J. C., Fazeli, B., ...&BikdeliBehnoodGuoYutao Harenberg Job Hu Yu Lip Gregory YH Roldan Vanessa. (2020). Guidance for the management of patients with vascular disease or cardiovascular risk factors and COVID-19: position paper from VAS-European independent foundation in angiology/vascular medicine. Thrombosis and haemostasis, 120(12), 1597-1628.
Avruscio, G., Camporese, G., Campello, E., Bernardi, E., Persona, P., Passarella, C., ...& COVID‐VTE study group. (2020). COVID‐19 and venous thromboembolism in intensive care or medical ward. Clinical and Translational Science, 13(6), 1108-1114.
Zhai, Z., Li, C., Chen, Y., Gerotziafas, G., Zhang, Z., Wan, J., ...& Wang,C. (2020). Prevention and treatment of venous thromboembolism associated with coronavirus disease 2019 infection: a consensus statement before guidelines. Thrombosis and haemostasis, 120(06), 937- 948.
Keane, G., & Dorman, T. (2022). Fatal pulmonary thromboembolism in asymptomatic COVID-19. Irish Journal of Medical Science (1971-), 1-7.
Libby, P., &Lüscher, T. (2020). COVID-19 is, in the end, an endothelial disease. European heart journal, 41(32), 3038-3044.
Teuwen, L. A., Geldhof, V., Pasut, A., &Carmeliet, P. (2020). COVID- 19: the vasculature unleashed. Nature Reviews Immunology, 20(7), 389- 391.
Lowenstein, C. J., & Solomon, S. D. (2020). Severe COVID-19 is a microvascular disease. Circulation, 142(17), 1609-1611.
Soy, M., Keser, G., Atagündüz, P., Tabak, F., Atagündüz, I., & Kayhan, S. (2020). Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment. Clinical rheumatology, 39(7), 2085-2094.
Lehnert, P., Lange, T., Møller, C. H., Olsen, P. S., & Carlsen, J. (2018). Acute pulmonary embolism in a national Danish cohort: increasing incidence and decreasing mortality. Thrombosis and haemostasis, 118(03), 539-546.
ayne, J. G., Tagalakis, V., Wu, C., & Lazo-Langner, A. (2021). Current estimates of the incidence of acute venous thromboembolic disease in Canada: a meta-analysis. Thrombosis Research, 197, 8-12.
Konstantinides, S. V., Meyer, G., Becattini, C., Bueno, H., Geersing, G. J., Harjola, V. P., ... & Zamorano, J. L. (2020). 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS) The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). European heart journal, 41(4), 543-603
Yevdokimova K, Poor HD. Pulmonary Thromboembolism in COVID-19. In: Herzog E (ed) Pulmonary Embolism. Springer, Cham. 2022.
Poissy, J., Goutay, J., Caplan, M., Parmentier, E., Duburcq, T., Lassalle, F.,...& Susen, S. (2020). Pulmonary embolism in patients with COVID- 19: awareness of an increased prevalence. Circulation, 142(2), 184-186.
Patell, R., Bogue, T., Koshy, A., Bindal, P., Merrill, M., Aird, W. C., ...& Zwicker, J. I. (2020). Postdischarge thrombosis and hemorrhage in patients with COVID-19. Blood, The Journal of the American Society of Hematology, 136(11), 1342-1346.
Roberts, L. N., Whyte, M. B., Georgiou, L., Giron, G., Czuprynska, J., Rea, C., ...& Arya, R. (2020). Postdischarge venous thromboembolism following hospital admission with COVID-19. Blood, The Journal of the American Society of Hematology, 136(11), 1347-1350.
Cui, S., Chen, S., Li, X., Liu, S., & Wang, F. (2020). Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. Journal of Thrombosis and Haemostasis, 18(6), 1421-1424.
Wang, C., Yu, C., Jing, H., Wu, X., Novakovic, V. A., Xie, R., & Shi, J. (2022). Long COVID: the nature of thrombotic sequelae determines the necessity of early anticoagulation. Frontiers in Cellular and Infection Microbiology, 12.
Suh, Y. J., Hong, H., Ohana, M., Bompard, F., Revel, M. P., Valle, C.,...& Yoon, S. H. (2021). Pulmonary embolism and deep vein thrombosis in COVID-19: a systematic review and meta-analysis. Radiology, 298(2), E70-E80.
Engelen, M. M., Vandenbriele, C., Balthazar, T., Claeys, E., Gunst, J., Guler, I., ...& Vanassche, T. (2021, April). Venous thromboembolism in patients discharged after COVID-19 hospitalization. In Seminars in thrombosis and hemostasis (Vol. 47, No. 04, pp. 362-371). 333 Seventh Avenue, 18th Floor, New York, NY 10001, USA: Thieme Medical Publishers, Inc..
Scudiero, F., Silverio, A., Di Maio, M., Russo, V., Citro, R., Personeni, D., ...& Network, C. I. (2021). Pulmonary embolism in COVID-19 patients: prevalence, predictors and clinical outcome. Thrombosis research, 198, 34-39.
Siddiqi, H. K., & Mehra, M. R. (2020). COVID-19 illness in native and immunosuppressed states: A clinical–therapeutic staging proposal. The journal of heart and lung transplantation, 39(5), 405-407.
Jose RJ, Manuel A. COVID-19 cytokine storm: the interplay between inflammation and coagulation. Lancet Respir Med. 2020;8(6):e46–7.
Di Micco, P., Russo, V., Carannante, N., Imparato, M., Rodolfi, S., Cardillo, G., &Lodigiani, C. (2020). Clotting factors in COVID-19: epidemiological association and prognostic values in different clinical presentations in an Italian cohort. Journal of clinical medicine, 9(5), 1371.