Phytochemical Profile, Antimicrobial, Antidiabetic and Anti-inflammatory Studies of Gynandropsis pentaphylla Leaves Extracts
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Abstract
Every medicinal plant species found potent for various biological properties. The current research work focused on to characterize and investigate the phytochemical and pharmacological properties of Gynandropsis pentaphylla leaves extracts of acetone, ethanol and ethyl acetate. The leaves of Gynandropsis pentaphylla was procured from agricultural terrain in the villages of North Karnataka, in the month of August to October and authentication done at Department of Botany, Karnataka State Akkamahadevi Women’s University, Vijayapura, Karnataka, India. The investigation recognizes the presence of alkaloids in acetone extract, glycosides, flavonoids, steroids, saponins, alkaloids in ethanol extract and steroids, glycosides, flavonoids in ethyl acetate extract. The findings from the extracts demonstrated notable antimicrobial against Staphylococcus aureus, Escherichia coli as bacterial strains and Fusarium sps as fungal strain, antidiabetic by α-amylase assay and anti-inflammatory property by hemolysis assay and found significant in ethanol extract compare to acetone and ethyl acetate extracts, hence indicating that ethanol extract is promising prospects for medicinal applications. The results of this study are expected to generate additional research in the fields of phytochemistry and therapeutic application
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References
Dakshayini PN, Roy UB, Kolgi RR, Singh SR, Sharma S, Shrivastava R and Patil SJ. Efficacy of Phytoextracts on female reproduction and impact on diabetes mellitus. Journal of Advanced Zoology, 2023, 44(4): 1154–1160.
Nataraj BT, Dave L, Badra A, Madhu, Mishra T, Shrivastava R and Patil SJ. Wild Indian medicinal plants and their biological studies. Bio Gecko - Journal for New Zealand Herpetology, 2023, 12(2): 01-06.
Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine, 2006; 27(1): 3-5. 4.
Thillaivanan S, Samraj K. Challenges, Constraints and opportunities in herbal medicines a review. International Journal of Herbal Medicine, 2014; 2(1): 21-22.
Mamedov N. Medicinal plants studies: history, challenges and prospective. In: Medicinal & Aromatic Thillaivanan S, Samraj K. Challenges, constraints and opportunities in herbal medicines – a Plants, 2012; 1(8): 1.
Surana KR, Ahire ED, Mahajan SK, Patil DM, Jadhav KR. Antimicrobial and anti-inflammatory action of flavonoids. The Flavonoids. 2024; 263.
Krupanidhi A.M., Patil SJ, Vagdevi HM. In Search of Novel Bioactive Moieties for their Antifertility and Anticancer Activities. In: Advances in Chemical Biology - An Overview of Research Milestones and Applications. Editors: Sadashiv S.O., Patil SJ. and Nandeshwarappa B.P. SHINEEKS Publishers eBooks, Las Vegas, USA: 2023; Vol 2, Pp.63-82.
Roy UB, Seethalaxmi R, Renuka Jyothi S, Dsouza MR, Mahishi P, Premalatha SJ, Patil SJ. Herbal medical product for metabolic diseases: A new pharmacological approach. Pakistan Heart Journal, 2023; 56(2): 1451-1450.
Guru Prasad V, Lavanya L, Patil SJ, Imran K, Reddy VD. Bioactive principles of Azadirachta indica leaves MeOH extract and their antibacterial property against Vibrio cholera strains. European Chemical Bulletin, 2023; 12 (Spl Iss 5): 1327-1341.
Premalatha SJ, Patil SJ. Isolation and characterization of pharmacological endophytic fungi from Cassia fistula leaves. Journal of Pharmaceutical Negative Results, 2022; 13(Spl. 10): 3594-3597.
Pushpa TC, Gupta AA, Shukla N, Gupta PC, Kumar S, Alice Sheba S, Sharma MK, Patil SJ. Evaluation of in vitro, anti-inflammatory and anti-oxidant activity on the aqueous and ethanolic extract of leaves of Hygrophila balsamica. China Petroleum Processing and Petrochemical Technology, 2023; 23(2): 2750-2764.
Kar NR, Roy UB, Patil SJ, Kolgi RR, Renuka Jyothi S, Verma S, Asif M, Prasad PD. Anti-urolithiatic activity of Cassia auriculata ethanolic seed extract in Wistar rats. Journal of Advanced Zoology, 2023; 44(S1), 929–935.
Eramma N, Patil SJ. Exploration of the biomolecules in roots of Flacourtia indica (Burm F) Merr. methanol extract by chromatography approach. Letters in Applied Nano BioScience, 2023; 12(4): 166.
Renuka Jyothi S, Malathi H, Patil SJ. Efficacy of graviola seed extract (Annona muricata: Annonaceae) on E-cadherin Gene regulation and cytotoxicity in MDA-MB-231 cell lines. Asian Journal of Pharmaceutics, 2023; 17(1): 38-42.
Renuka Jyothi S, Mahishi P, Shanmugam VM, Kumar A, Singh SR, Shrivastava R, Patil SJ. Role and application of Indian medicinal plants in women health management. International Journal of Food and Nutritional Sciences, 2023; 12(1): 2405-2414.
Premalatha SJ, Patil SJ. Anti-Inflammatory, Analgesic and skeletal muscle relaxant activities of Cassia fistula leaves extracts. NeuroQuantology, 2022; 20(6): 11135-11141.
Patil SJ, Renuka Jyothi S, Sadashiv SO, Vishwantaha T, Adam JK, Naidu SBK. Antioxidant Potential of Zephyranthes citrina seed extract in Saccharomyces cerevisiae's oxidative stress response system seeds. Current Concepts in Biotechnology and Pharmacy, 2023; 17(Supl Iss 3A): 1129 – 1140.
Patil SJ, Patil SB. Effect of Oxalis corniculata whole plant extracts on fertility regulation in female albino rats. Journal of Advanced Scientific Research, 2012; 3(1): 58-61.
Sharangouda, Patil SJ. Post-coital antifertility activity of Citrus medica seeds The Bioscan- An International Journal of Life Sciences, 2007; 2(4):304-310.
Farnsworth NR. Biological and phytochemical screening of plants. Journal of Pharm Sciences, 1966; 55(3): 225-76.
Harborne JB. Phytochemical methods: a guide to modern techniques of plant analysis. 2nd ed. London: Chapman and Hall, Ltd; 1973.
Sharangouda, Patil SB. Phytochemical screening and antifertility activity of various extracts of Citrus medica (Lemon) seeds in albino rats. Advances in Pharmacology and Toxicology, 2007; 8(2): 71-4.
Haleshappa R, Patil SJ, Murthy SKM. Phytochemical analysis, in vitro evaluation of antioxidant and free radical scavenging activity of Simarouba glauca seeds. Advances in Pharmacology and Pharmacy, 2021; 9(1):01-08.
Haleshappa R, Sajeeda N, Kolgi RR, Patil SJ, Murthy SKM. 2022. Phytochemicals, anti-nutritional factors and proximate analysis of Simarouba glauca seeds. International Advanced Research Journal in Science, Engineering and Technology, 2022; 09(3): 218-227.
Morabad RB, Patil SJ. Elemental profile analysis of some traditional medicinal plants of Karnataka using AAS technique. International Journal of Current Pharmaceutical Research, 2016;09(01): 59-61.
Sharangouda, Patil SB. Antifertility principles from Citrus medica seeds: pharmacological and phytochemical studies. Asian Journal of Experimental Sciences, 2010; 24(1): 155-161.
Londonkar RL, Patil SJ, Patil SB. Phytochemical and contraceptive property of Sida acuta Burm Fi. Ind. in albino rats. International Journal of Pharmatech Research, 2009; 1(4): 1260-1266.
Sreedharan S, Gothe S, Aier K, Kirankumar SV, Kalva PK, Patil SJ, Bioactive molecules and antimicrobial studies of Rhus semialata seeds. Research Journal of Medicinal Plants, 2020; 13(1): 10-17.
Haleshappa R, Patil SJ, Usha T, Murthy SKM, Phytochemicals, antioxidant profile and GCMS analysis of ethanol extract of Simarouba glauca seeds. Asian Journal of Biological and Life Sciences, 2020; 9(3): 379-385.
Kolgi RR, Haleshappa R, Sajeeda N, Keshamma E, Karigar CS, Patil SJ. Antioxidant and anticancer properties of ethanol extracts of Leucas aspera. Asian Journal of Biological and Life Sciences, 2021; 10(1): 165-171.
Karishma KB, Afreen Banu M, Venkatesh CN, Prakruthi, Siddalingeshwara KG, Sadashiv SO, Patil SJ. Comparative analysis of phytochemical potential in ethanol extract of Cosmos bipinnatus and Pteries fauriei leaves. Advances in Pharmacology and Toxicology, 2023;24 (1):25-32.
Hanchinalmath JV, D’mello D, Kirankumar SV, Pramod T, Patil SJ, Filaricidal activity of phytochemicals against lymphatic filariasis. In: Neglected Tropical Diseases and Phytochemicals in Drug Discovery. Part III: Helminth Infections. 1st Edition, John Wiley & Sons, Canada, p. 245-270, 2022.
Patil SJ, Venkatesh S, Vishwanatha T, Banagar SR, Banagar SB, Patil SB. GCMS analysis of bioactive constituents from the petroleum ether extract of Citrus medica seeds. World Journal of Pharmacy and Pharmaceutical Sciences, 2014;3(2): 1239-1249.
Garg S, Hari V, Suseela R, Menon S, Gaviraj EN, Tiwari KJ, Rajashekar M, Yadav L, Patil SJ. Studies on the effects of Adansonia digitata Lin's fruits on diabetes. Journal of Advanced Zoology, 2023;44(S4): 52-64.
Bairagi JH, Haritha G, Yadav L, Garg S, Rani V, Pulipati S, Kolgi RR, Pundir R, Patil SJ. To study of Artemisia nilagirica leaves for their antithyroid, oxidative and antihyperglycemic properties. Journal of Advanced Zoology, 2023; 44(S4): 40–51.
Chirumamilla P, Vankudoth S, Dharavath SB. Dasari R, Taduri S. In vitro anti-inflammatory activity of green synthesized silver nanoparticles and leaf methanolic extract of Solanum khasianum Clarke. Proceedings of National Academy of Science, India, Section B: Biological Sciences. 2022; 92: 301–307