Identification of B-cell and T-cell specific peptide vaccine for Pneumocystis jirovecii

Abstract

Pneumocystis jirovecii is a fungal pathogen that causes a severe lung infection primarily in individuals with compromised immune systems. The high morbidity and mortality associated with Pneumocystis jirovecii pneumonia (PJP) highlight the need for effective preventive strategies.Peptide vaccines offer several advantages, including their specificity, reduced risk of adverse reactions, and potential for customization. To develop an effective peptide vaccine, it is crucial to identify B-cell and T-cell specific epitopes that can stimulate the immune system to produce antibodies and activate T-cells against Pneumocystis jirovecii.

The aim of identifying B-cell and T-cell specific peptide vaccine for Pneumocystis jirovecii is to develop an effective immunization strategy against this fungal pathogen.