Synergistic Effects of Vinca Rosea and Triphala Formulations on Wound Healing: A Preclinical Study
DOI:
https://doi.org/10.53555/jaz.v46i1.5128Keywords:
Wound healing, Vinca Rosea, Triphala, Antioxidant activity, Pro-inflammatory cytokines.Abstract
Wound healing is a multifaceted biological process essential for restoring skin integrity after injury. The combination of Vinca Rosea and Triphala offers a novel approach for enhancing wound healing due to their complementary pharmacological properties. This study evaluates the wound-healing efficacy of various formulations of Vinca Rosea and Triphala in a full-thickness excision wound model in Wistar rats. The experimental groups were treated with formulations of different ratios, and wound healing was assessed through parameters such as wound contraction, epithelialization time, antioxidant enzyme activity (SOD, catalase), and pro-inflammatory cytokine levels (TNF-α, IL-6). Histological analysis revealed enhanced collagen deposition, reduced inflammation, and accelerated re-epithelialization in groups treated with higher Vinca Rosea concentrations. Among the tested formulations, the 3:1 ratio exhibited superior results, achieving the highest wound contraction (85%) and shortest epithelialization time (11 days). This study highlights the synergistic effects of Vinca Rosea and Triphala in promoting wound healing, with the 3:1 formulation emerging as the most effective. These findings provide a basis for developing natural therapeutic formulations for wound management.
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