Teratogenic Effects of Potassium bromate On Drosophila melanogaster
DOI:
https://doi.org/10.53555/jaz.v45i6.4998Keywords:
Teratogen, Potassium bromate, Developmental time (DT), Viability, Drosophila melanogaster and aberrant phenotypeAbstract
In recent years, there has been growing concern about the toxic potential of substances consumed by humans. One such substance that has attracted attention is potassium bromate (KBrO3) used as a food additive, water disinfectant, and in pharmaceutical industries, has been extensively studied due to its detrimental impact on human health. It could potentially cause serious teratogenic effects on embryonic development. Certain pharmacological and physiological characteristics of fruit flies (Drosophila melanogaster) are comparable to those of humans. So, to study the teratogenic potentials, different concentrations of KBrO3 (15mM to 30mM) were exposed to the egg to adult stages of fruit fly. This study assessed life-history parameters and revealed significant increases in larval and pupal mortality, extended developmental durations, smaller larval, pupal, and adult sizes, deformities in pupae and aberrant phenotype in adults, all in a concentration-dependent manner. The results showed that KBrO3 treatment (15mM to 30mM) increased the developmental time of egg to pupae (p < 0.0001) and egg to adult (p = 0.0017). The viability rate of pupae (p < 0.0001); adults (p < 0.0001), the length (p< 0.0001) and width (p < 0.0001) of larvae and pupae decreased significantly as compared to the control group. These findings suggest that prenatal exposure to KBrO3 has clear teratogenic effects on fruit flies, indicating potential risks to human health if KBrO3 is used in any application.
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