A Review On Association Of Diet And Lifestyle With The Occurence Of Hepatocarcinoma
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Abstract
The unrestrained development of malignant cells within the liver characterizes hepatocellular carcinoma, often known as liver cancer, which is a severe global health problem. High consumption of processed foods, sugary drinks, and red meats has been associated with an enhanced risk due to their propensity to generate inflammation and oxidative stress, which promote carcinogenesis. The anti-inflammatory and antioxidant properties of diets rich in fruits, vegetables, whole grains, and lean proteins, on the other hand, have protective effects. Lifestyle decisions further contribute to this malignancy because drinking alcohol directly damages liver cells and raises the chance of cirrhosis. Additionally, obesity, which is commonly linked to poor dietary choices, increases the risk by leading to insulin resistance and fatty liver disease. The risk of liver carcinogenesis is reported to get reduced by regular exercise. Men often experience 2 to 4 times the rate of liver cancer as women. An effort must be made to improve prevention, early diagnosis, and treatment strategies in the fight against this fatal condition. This abstract will concentrate on the epidemiology, risk factors, present treatments, and future research possibilities of liver cancer in order to provide a concise overview of the disease.
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References
Aleksandrova, K., Stelmach-Mardas, M., & Schlesinger, S. (2016). Obesity and Liver Cancer. Recent Results in Cancer Research,208, 177–198. DOI:10.1007/978-3-319-42542-9_10
AlEssa, H. B., Bhupathiraju, S. N., Malik, V. S., Wedick, N. M., Campos, H., Rosner, B., … Hu, F. B. (2015). Carbohydrate quality and quantity and risk of type 2 diabetes in US women. The American Journal of Clinical Nutrition, 102(6), 1543–1553. DOI:10.3945/ajcn.115.116558
AlEssa, H. B., Cohen, R., Malik, V. S., Adebamowo, S. N., Rimm, E. B., Manson, J. E., … Hu, F. B. (2018). Carbohydrate quality and quantity and risk of coronary heart disease among US women and men. The American Journal of Clinical Nutrition, 107(2), 257–267. DOI:10.1093/ajcn/nqx060
Bhardwaj, R. K., GLAESER, H., BECQUEMONT, L., KLOTZ, U., GUPTA, S. K., & FROMM, M. F. (2002). Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4.Journal of Pharmacology and Experimental Therapeutics, 302(2), 645–650. DOI:10.1124/jpet.102.034728
Boon, T., Coulie, P. G., Eynde, B. J. V. den, & Bruggen, P. van der. (2006). HUMAN T CELL RESPONSES AGAINST MELANOMA. Annual Review of Immunology, 24(1), 175–208. DOI:10.1146/annurev.immunol.24.021605.090733
Bouvard, V., Loomis, D., Guyton, K. Z., Grosse, Y., Ghissassi, F. E., Benbrahim-Tallaa, L., … Straif, K. (2015). Carcinogenicity of consumption of red and processed meat. The Lancet Oncology, 16(16), 1599–1600. DOI:10.1016/s1470-2045(15)00444-1
Bravi, F., Bosetti, C., Tavani, A., Gallus, S., & La Vecchia, C. (2013). Coffee reduces risk for hepatocellular carcinoma: an updated meta-analysis. Clinical gastroenterology and hepatology, 11(11), 1413-1421. DOI:https://doi.org/10.1016/j.cgh.2013.04.039
Bravi, F., Tavani, A., Bosetti, C., Boffetta, P., & La Vecchia, C. (2017). Coffee and the risk of hepatocellular carcinoma and chronic liver disease. European Journal of Cancer Prevention, 26(5), 368-377. DOI: 10.1097/CEJ.0000000000000252
Center, M. M., & Jemal, A. (2011). International Trends in Liver Cancer Incidence Rates. Cancer Epidemiology Biomarkers & Prevention, 20(11), 2362–2368. DOI:10.1158/1055-9965.epi-11-0643
Chen, Y., Huang, Y., Reiberger, T., Duyverman, A. M., Huang, P., Samuel, R., … Duda, D. G. (2014). Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. Hepatology, 59(4), 1435–1447. DOI:10.1002/hep.26790
Chuang, S. C., Lee, Y. C. A., Wu, G. J., Straif, K., &Hashibe, M. (2015). Alcohol consumption and liver cancer risk: a meta-analysis. Cancer Causes & Control, 26, 1205-1231. DOI: 10.1007/s10552-015-0615-3
Coffelt, S. B., & de Visser, K. E. (2016). Revving Up Dendritic Cells while Braking PD-L1 to Jump-Start the Cancer-Immunity Cycle Motor. Immunity, 44(4), 722–724. DOI:10.1016/j.immuni.2016.03.014
Davis, M. E., Chen, Z., & Shin, D. M. (2008). Nanoparticle therapeutics: an emerging treatment modality for cancer. Nature Reviews Drug Discovery, 7(9), 771–782. DOI:10.1038/nrd2614
De Castro, G. S., & Calder, P. C. (2018). Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids. Clinical Nutrition, 37(1), 37–55. DOI:10.1016/j.clnu.2017.01.006
Duarte Salles, T., Fedirko, V., Stepien, M., Trichopoulou, A., Bamia, C., Lagiou, P., ... & Jenab, M. (2014). Dairy products and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition. International journal of cancer, 135(7), 1662-1672. DOI: 10.1002/ijc.28812
El-Serag, H. B., Marrero, J. A., Rudolph, L., & Reddy, K. R. (2008). Diagnosis and Treatment of Hepatocellular Carcinoma. Gastroenterology, 134(6), 1752-1763. DOI:10.1053/j.gastro.2008.02.090
Fedirko, V., Lukanova, A., Bamia, C., Trichopolou, A., Trepo, E., Nöthlings, U., … Jenab, M. (2012). Glycemic index, glycemic load, dietary carbohydrate, and dietary fiber intake and risk of liver and biliary tract cancers in Western Europeans. Annals of Oncology, 24(2), 543–553. DOI:10.1093/annonc/mds434
Godos, J., Micek, A., Marranzano, M., Salomone, F., Del Rio, D., & Ray, S. (2017). Coffee consumption and risk of biliary tract cancers and liver cancer: A dose–response meta-analysis of prospective cohort studies. Nutrients, 9(9), 950. DOI: 10.3390/nu9090950
Heaney, R. P., McCARRON, D. A., Dawson-Hughes, B., Oparil, S., Berga, S. L., Stern, J. S., ... & Rosen, C. J. (1999). Dietary changes favorably affect bone remodeling in older adults. Journal of the American Dietetic Association, 99(10), 1228-1233. DOI:10.1016/S0002-8223(99)00302-8
Hoppe, C., Mølgaard, C., Juul, A., & Michaelsen, K. F. (2004). High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys. European Journal of Clinical Nutrition, 58(9), 1211-1216. DOI:10.1038/sj.ejcn.1601948
Huang, R. X., Duan, Y. Y., & Hu, J. A. (2015). Fish intake and risk of liver cancer: a meta-analysis. PloS one, 10(1), e0096102. DOI: 10.1371/journal.pone.0096102
Kennedy, O. J., Roderick, P., Buchanan, R., Fallowfield, J. A., Hayes, P. C., & Parkes, J. (2017). Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose–response meta-analysis. BMJ open, 7(5), e013739. DOI: 10.1136/bmjopen-2016-013739
Kudo, M. (2016). Immune Checkpoint Blockade in Hepatocellular Carcinoma: 2017 Update. Liver Cancer, 6(1), 1–12. DOI:10.1159/000449342
Lai, G. Y., Weinstein, S. J., Albanes, D., Taylor, P. R., Virtamo, J., McGlynn, K. A., & Freedman, N. D. (2014). Association of serum α-tocopherol, β-carotene and retinol with liver cancer incidence and chronic liver disease mortality. British Journal of Cancer, 111(11), 2163–2171. DOI:10.1038/bjc.2014.365
Li, X., Sun, R., & Liu, R. (2019). Natural products in Licorice for the therapy of liver diseases: Progress and future opportunities. Pharmacological Research, 144, 210-226. DOI:10.1016/j.phrs.2019.04.025
Liu, W., Zhao, X., Chen, Q., Li, Y., Tang, H., Liu, X., & Yang, X. (2014). Codelivery of doxorubicin and curcumin with lipid nanoparticles results in improved efficacy of chemotherapy in liver cancer. International Journal of Nanomedicine, 10, 257-270. DOI:10.2147/ijn.s73322
Liu, Y., Warren Andersen, S., Wen, W., Gao, Y.-T., Lan, Q., Rothman, N., … Zheng, W. (2016). Prospective cohort study of general and central obesity, weight change trajectory and risk of major cancers among Chinese women. International Journal of Cancer, 139(7), 1461–1470. DOI:10.1002/ijc.30187
Livney, Y. D., &Assaraf, Y. G. (2013). Rationally designed nanovehicles to overcome cancer chemoresistance. Advanced Drug Delivery Reviews, 65(13-14), 1716–1730. DOI:10. 1016/j.addr.2013.08.006
Loomba, R., Yang, H. I., Su, J., Brenner, D., Barrett-Connor, E., Iloeje, U., & Chen, C. J. (2013). Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. American journal of epidemiology, 177(4), 333-342. DOI: 10.1093/aje/kws252
Luo, J., Yang, Y., Liu, J., Lu, K., Tang, Z., Liu, P., ... & Zhu, Y. (2014). Systematic review with meta‐analysis: meat consumption and the risk of hepatocellular carcinoma. Alimentary pharmacology & therapeutics, 39(9), 913-922. DOI: 10.1111/apt.12678
Luo, J., Yang, Y., Liu, J., Lu, K., Tang, Z., Liu, P., … Zhu, Y. (2014). Systematic review with meta-analysis: meat consumption and the risk of hepatocellular carcinoma. Alimentary Pharmacology & Therapeutics, 39(9), 913–922. DOI:10.1111/apt.12678
Ma, J., Giovannucci, E., Pollak, M., Chan, J. M., Gaziano, J. M., Willett, W., & Stampfer, M. J. (2001). Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men. Journal of the National Cancer Institute, 93(17), 1330-1336.DOI:10.1093/jnci/93.17.1330
Minno, M. N. D. D., Russolillo, A., Lupoli, R., Ambrosino, P., Minno, A.C., & Tarantino, G., (2012). Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease. World Journal of Gastroenterology, 18(41), 5839. doi:10.3748/wjg.v18.i41.5839.
Mittal, S., & El-Serag, H. B. (2013). Epidemiology of Hepatocellular Carcinoma. Journal of Clinical Gastroenterology, 47, S2–S6. DOI:10.1097/mcg.0b013e3182872f29
Miuma, S., Ichikawa, T., Arima, K., Takeshita, S., Muraoka, T., Matsuzaki, T., … Nakao, K. (2012). Branched-chain amino acid deficiency stabilizes insulin-induced vascular endothelial growth factor mRNA in hepatocellular carcinoma cells. Journal of Cellular Biochemistry, 113(10), 3113–3121. DOI:10.1002/jcb.24188
Mozaffarian, R. S., Lee, R. M., Kennedy, M. A., Ludwig, D. S., Mozaffarian, D., & Gortmaker, S. L. (2013). Identifying whole grain foods: a comparison of different approaches for selecting more healthful whole grain products. Public Health Nutrition, 16(12), 2255–2264. DOI:10.1017/s1368980012005447
Pan, Q.-Z., Pan, K., Wang, Q.-J., Weng, D.-S., Zhao, J.-J., Zheng, H.-X., … Xia, J.-C. (2015). Annexin A3 as a Potential Target for Immunotherapy of Liver Cancer Stem-Like Cells. STEM CELLS, 33(2), 354–366. DOI:10.1002/stem.1850
Petrick, J. L., Campbell, P. T., Koshiol, J., Thistle, J. E., Andreotti, G., Beane-Freeman, L. E., … McGlynn, K. A. (2018). Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project. British Journal of Cancer, 118(7), 1005–1012. DOI:10.1038/s41416-018-0007-z
Polesel, J., Talamini, R., Montella, M., Maso, L. D., Crovatto, M., Parpinel, M., … Franceschi, S. (2007). Nutrients intake and the risk of hepatocellular carcinoma in Italy. European Journal of Cancer, 43(16), 2381–2387. DOI:10.1016/j.ejca.2007.07.012
Reddy, L. H., & Couvreur, P. (2011). Nanotechnology for therapy and imaging of liver diseases. Journal of Hepatology, 55(6), 1461–1466. DOI:10.1016/j.jhep.2011.05.039
Ren, M., Ye, L., Hao, X., Ren, Z., Ren, S., Xu, K., & Li, J. (2014). Polysaccharides from Tricholoma matsutake and Lentinus edodes enhance 5-fluorouracil-mediated H22 cell growth inhibition. Journal of Traditional Chinese Medicine, 34(3), 309–316. DOI:10.1016/s0254-6272(14)60095-9
Sawada, N., Inoue, M., Iwasaki, M., Sasazuki, S., Shimazu, T., Yamaji, T., … Tsugane, S. (2012). Consumption of n-3 Fatty Acids and Fish Reduces Risk of Hepatocellular Carcinoma. Gastroenterology, 142(7), 1468–1475. DOI:10.1053/j.gastro.2012.02.018
Shan, J., Shen, J., Liu, L., Xia, F., Xu, C., Duan, G., … Qian, C. (2012). Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma. Hepatology, 56(3), 1004–1014. DOI:10.1002/hep.25745
Siegel, R. L., Miller, K. D., & Jemal, A. (2019). Cancer statistics, 2019. CA: a cancer journal for clinicians, 69(1), 7-34. DOI:10.3322/caac.21551
Singh, R., Banerjee, S., Singh, S. K., Chowdhury, I., & Lillard Jr, J. W. (2017). Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer. Frontiers in Bioscience, 9(2), 235–245. DOI:10.2741/e798
Singh, S. K., Banerjee, S., Acosta, E. P., Lillard, J. W., & Singh, R. (2017). Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway.Oncotarget, 8(10), 17216-17228. DOI:10.18632/oncotarget.15303
Singh, S. K., Lillard Jr, J. W., & Singh, R. (2018). Reversal of drug resistance by planetary ball milled (PBM) nanoparticle loaded with resveratrol and docetaxel in prostate cancer. Cancer Letters, 427, 49–62. DOI:10.1016/j.canlet.2018.04.017
Singh, S., Singh, K, S., Lillard Jr, J. W., & Singh, R. (2017). Drug delivery approaches for breast cancer. International Journal of Nanomedicine, Volume 12, 6205–6218. DOI:10.2147/ijn.s140325
Soerjomataram, I., Oomen, D., Lemmens, V., Oenema, A., Benetou, V., Trichopoulou, A., … de Vries, E. (2010). Increased consumption of fruit and vegetables and future cancer incidence in selected European countries. European Journal of Cancer, 46(14), 2563–2580. DOI:10.1016/j.ejca.2010.07.026
Song, M., & Giovannucci, E. (2018). Substitution analysis in nutritional epidemiology: proceed with caution. European Journal of Epidemiology, 33(2), 137–140. DOI:10.1007/s10654-018-0371-2
Starley, B. Q., Calcagno, C. J., & Harrison, S. A. (2010). Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection. Hepatology, 51(5), 1820–1832. DOI:10.1002/hep.23594
Sugiyama, K., Yu, L., &Nagasue, N. (1998). Direct effect of branched‐chain amino acids on the growth and metabolism of cultured human hepatocellular carcinoma cells. Nutrition and Cancer, 31(1), 62–68. DOI:10.1080/01635589809514679
Takami, T., Yamasaki, T., Saeki, I., Matsumoto, T., Suehiro, Y., &Sakaida, I. (2016). Supportive therapies for prevention of hepatocellular carcinoma recurrence and preservation of liver function. World Journal of Gastroenterology,22(32), 7252–7263. DOI: 10.3748/wjg.v22.i32.7252
Turati, F., Galeone, C., Rota, M., Pelucchi, C., Negri, E., Bagnardi, V., ... & La Vecchia, C. (2014). Alcohol and liver cancer: a systematic review and meta-analysis of prospective studies. Annals of oncology, 25(8), 1526-1535. DOI: 10.1093/annonc/mdu020
Vogtmann, E., Li, H. L., Shu, X. O., Chow, W. H., Ji, B. T., Cai, H., … Xiang, Y. B. (2012). Dietary glycemic load, glycemic index, and carbohydrates on the risk of primary liver cancer among Chinese women and men. Annals of Oncology, 24(1), 238–244. DOI:10.1093/annonc/mds287
Wolonciej, M., Milewska, E., & Roszkowska-Jakimiec, W. (2016). Trace elements as an activator of antioxidant enzymes.PostepyHig Med Dosw, 70, 1483–1498. DOI:10.5604/17322693.1229074
Yang, B., Petrick, J. L., Kelly, S. P., Graubard, B. I., Freedman, N. D., & McGlynn, K. A. (2017). Adiposity across the adult life course and incidence of primary liver cancer: The NIH-AARP cohort. International Journal of Cancer, 141(2), 271–278. DOI:10.1002/ijc.30737
Yang, C. S., Wang, X., Lu, G., & Picinich, S. C. (2009). Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nature Reviews Cancer, 9(6), 429-439. DOI: 10.1038/nrc2641
Yang, W., Sui, J., Ma, Y., Simon, T. G., Chong, D., Meyerhardt, J. A., ... & Zhang, X. (2020). A prospective study of dairy product intake and the risk of hepatocellular carcinoma in US men and women. International journal of cancer, 146(5), 1241-1249. DOI: 10.1002/ijc.32423
Zhou, Y., Li, Y., Zhou, T., Zheng, J., Li, S., & Li, H.-B. (2016). Dietary Natural Products for Prevention and Treatment of Liver Cancer. Nutrients, 8(3), 156. DOI:10.3390/nu8030156