The Role of Activated Partial Thromboplastin Time (APTT) and Prothrombin Time (PT) in Evaluating Outcome Among Hospitalized Patients with Snake Bite

Abstract

Background: The considerable morbidity and death caused by snakebite envenomation is a global public health concern. Coagulopathy is a frequent complication in snakebite cases, although research on how well it predicts clinical outcomes is lacking. Activated Partial Thromboplastin Time (APTT) and Prothrombin Time (PT), in particular, are the focus of this study's investigation of the relevance of coagulation tests in evaluating outcomes for hospitalized snakebite patients. Methods: A retrospective cohort study with 200 patients who had been bitten by snakes and 200 controls was carried out. Clinical outcomes, such as severe bleeding, organ failure, and mortality, were evaluated together with the collection of APTT and PT data. The predictive usefulness of APTT and PT was assessed using statistical methods, such as logistic regression and ROC curve analysis. Results: When compared to controls, patients who had been bitten by snakes had significantly extended APTT and PT values. Extreme bleeding, organ failure, and mortality were all associated with abnormal APTT and PT readings. The most suitable cutoff values for risk stratification were determined through ROC curve analysis. Conclusion: The clinical importance of coagulopathy in snakebite envenomation is highlighted in this study's conclusion. The prognostic indicators APTT and PT show promise for identifying patients at higher risk of adverse outcomes, guiding prompt therapies, and enhancing patient care.