Formulation and Development of Transdermal Patches of Glibenclamide and Comparative Effect of Various Herbal Extracts on Ex Vivo Release

Abstract

In the pursuit of crafting and assessing transdermal patches containing Glibenclamide, this investigation was chiefly orchestrated. Diverse polymers were harnessed in this endeavour, and a pivotal exploration into the influence of extracts derived from Capsicum Fruit extract on the bioavailability of Glibenclamide was conducted. The congruence between the physical and chemical attributes of the medication and the foundation of the patches underwent scrupulous scrutiny via Infrared Spectroscopy (FTIR). The findings yielded no discordance in physical and chemical properties between the medication and the patch base. A comprehensive evaluation of the formulated transdermal patches ensued, encompassing assessments of weight variance, plumpness, folding endurance, humidity levels, moisture retention, ex-vivo drug release, and ex-vivo drug absorption. The discerning diffusion analyses were executed through the utilization of the Franz Diffusion cell and Everted gut Sac method. The most optimal formulation, denoted as F15, exhibited the following characteristics: a thickness of 0.247±0.005mm, uniform weight distribution at 0.170±0.102gm, moisture uptake of 7.312±1.12%, moisture content at 5.045±0.214%, and drug content measuring 80.80±0.91%. Furthermore, it demonstrated an impressive folding endurance of 25±3.33. The pinnacle of its performance manifested in a cumulative drug release percentage of 70.74±1.15 within an 8-hour timeframe and an absorption rate of 4.341±0.34% in a span of 120 minutes.