THE EFFECT OF DIFFERENT POWERS OF LOW-LEVEL LASER THERAPY ON WOUND HEALING OF DIABETIC RATS- A COMPARATIVE STUDY

Abstract

Tissue healing is a complex process involving local and systemic responses. Inadequate of inappropriate wound healing is a headache to many surgeons especially in compromised patients. Several technologies have been tested for their effect on improving and enhancing wound healing. The use of low-level laser therapy for example has been shown to be effective in modulating both local and systemic response healing responses.

Aim: This study aims to evaluate the effect of different powers of low-level laser therapy on wound healing in diabetic rats.

Methodology: Streptozotocin (45 mg/kg body weight) was intraperitoneally applied for diabetes induction. A full-thickness skin wound (2 × 2 cm2) was aseptically created with a scalpel in diabetic rats on the shaved back of the animals. The wounded diabetic rats were treated with low-level laser therapy (LLLT) for 14 days. The wound closure percent was calculated during the course of the experiment on days 1, 7, and 14.

Results: Clinical observation of skin lesion samples of the animals showed that skin lesions of the group (A) (control) exhibited an early-phase tissue repair pattern, with the formation of a whitish crust, with slightly elevated rims and a reddish core, group (B) and (C) wounds, which were showed complete tissue repair, showing scars with evident rims and a central portion slightly unleveled, These results suggest that LLLT is an efficacious method of tissue repair modulation, significantly contributing to more rapid and organized healing of tissues.