Effectiveness of SNEDDS to Increased Oral Bioavailability in Antihypertension Agents: A Review

Abstract

Hypertension is a disease that is well known, but the drug solubility of oral Antihypertension drugs has problems with their solubility. The aim of this study was to determine the effect of the SNEDDS formulation on oral Antihypertension drugs. The research method used is a systematic literature review method with PRISMA guidelines using reputable databases namely PubMed, Scopus, and ScienceDirect. From the results of the research studies conducted, the value of the particle size in the SNEDDS preparation of oral Antihypertension drugs is in the range of 13.91–169 nm with a PDI value of ≤ 0.5, which meets the particle size requirements for SNEDDS < 200 nm, and the zeta potential indicating > ± 30 mV, an increase in AUC, Cmax, and Tmax rating in the SNEDDS preparation. This result that the application of SNEDDS to oral Antihypertension drugs is effective in increasing the bioavailability of BCS class II and IV drugs.